MedKoo Cat#: 124391 | Name: AC1-IN-1
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor

Chemical Structure

AC1-IN-1
AC1-IN-1
CAS#2762422-55-7

Theoretical Analysis

MedKoo Cat#: 124391

Name: AC1-IN-1

CAS#: 2762422-55-7

Chemical Formula: C18H18FN5O2

Exact Mass: 355.1445

Molecular Weight: 355.37

Elemental Analysis: C, 60.84; H, 5.11; F, 5.35; N, 19.71; O, 9.00

Price and Availability

Size Price Availability Quantity
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 3,650.00 2 Weeks
1g USD 5,650.00 2 Weeks
2g USD 7,850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
AC1-IN-1; AC1-IN 1; AC1 IN-1;
IUPAC/Chemical Name
N-(1-(4-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-3-methyl-1H-pyrazol-5-yl)-2-fluoro-5-methylbenzamide
InChi Key
DMYBQBANWFHYSM-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18FN5O2/c1-4-12-9-16(25)22-18(20-12)24-15(8-11(3)23-24)21-17(26)13-7-10(2)5-6-14(13)19/h5-9H,4H2,1-3H3,(H,21,26)(H,20,22,25)
SMILES Code
CCC1=CC(NC(N2N=C(C=C2NC(C3=C(C=CC(C)=C3)F)=O)C)=N1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Scott JA, Soto-Velasquez M, Hayes MP, LaVigne JE, Miller HR, Kaur J, Ejendal KFK, Watts VJ, Flaherty DP. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022 Mar 24;65(6):4667-4686. doi: 10.1021/acs.jmedchem.1c01759. Epub 2022 Mar 10. PMID: 35271288; PMCID: PMC9390083.