MedKoo Cat#: 124314 | Name: NPD-2975
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPD-2975 is a potent Aantitrypanosomal agent with in vivo efficacy. NPD-2975 has an in vitro IC50 of 70 nM against T. b. brucei with no apparent toxicity against human MRC-5 lung fibroblasts.

Chemical Structure

NPD-2975
NPD-2975
CAS#521297-42-7

Theoretical Analysis

MedKoo Cat#: 124314

Name: NPD-2975

CAS#: 521297-42-7

Chemical Formula: C14H13FN4O

Exact Mass: 272.1100

Molecular Weight: 272.28

Elemental Analysis: C, 61.76; H, 4.81; F, 6.98; N, 20.58; O, 5.88

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 550.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
NPD-2975; NPD 2975; NPD2975
IUPAC/Chemical Name
5-(4-fluorophenyl)-3-isopropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChi Key
OJEVXJSJYBCDSR-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H13FN4O/c1-7(2)10-11-12(19-18-10)14(20)17-13(16-11)8-3-5-9(15)6-4-8/h3-7H,1-2H3,(H,18,19)(H,16,17,20)
SMILES Code
FC1=CC=C(C2=NC(C(C(C)C)=NN3)=C3C(N2)=O)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zheng Y, van den Kerkhof M, van der Meer T, Gul S, Kuzikov M, Ellinger B, de Esch IJP, Siderius M, Matheeussen A, Maes L, Sterk GJ, Caljon G, Leurs R. Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy. J Med Chem. 2023 Jul 20. doi: 10.1021/acs.jmedchem.3c00161. Epub ahead of print. PMID: 37471520.