UBE-1099 | Keap1−Nrf2 inhibitor

MedKoo Cat#: 124280 | Name: UBE-1099

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UBE-1099 is a Keap1−Nrf2 inhibitor with IC50 = 47.4 nM.

Chemical Structure

UBE-1099

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 124280

Name: UBE-1099

CAS#: N/A

Chemical Formula: C33H37F3N4O3

Exact Mass: 594.2800

Molecular Weight: 594.68

Elemental Analysis: C, 66.65; H, 6.27; F, 9.58; N, 9.42; O, 8.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

UBE-1099; UBE 1099; UBE1099

IUPAC/Chemical Name

3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-7-(trifluoromethyl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid

InChi Key

MUGQGPVBPDRCSM-MIJJZIGMSA-N

InChi Code

InChI=1S/C33H37F3N4O3/c1-7-25-18-40(17-23-15-24(33(34,35)36)10-13-28(23)43-25)16-22-14-21(9-8-19(22)2)29(32(4,5)31(41)42)26-11-12-27-30(20(26)3)37-38-39(27)6/h8-15,25,29H,7,16-18H2,1-6H3,(H,41,42)/t25-,29?/m1/s1

SMILES Code

CN1C2=CC=C(C(C3=CC=C(C)C(CN4C[C@@H](CC)OC(C=CC(C(F)(F)F)=C5)=C5C4)=C3)C(C)(C)C(O)=O)C(C)=C2N=N1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 594.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Kaseda S, Sannomiya Y, Horizono J, Kuwazuru J, Suico MA, Ogi S, Sasaki R, Sunamoto H, Fukiya H, Nishiyama H, Kamura M, Niinou S, Koyama Y, Nara F, Shuto T, Onuma K, Kai H. Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model. Kidney360. 2021 Dec 1;3(4):687-699. doi: 10.34067/KID.0004572021. PMID: 35721612; PMCID: PMC9136903.