Synonym
SCHEMBL22445723; GTPL12520; NSC808568; TG8260; NSC-808568; TG8-260; Compound 2f
IUPAC/Chemical Name
4-(1H-imidazol-4-yl)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
InChi Key
XMWMPTMQNJXLNV-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20N4O/c1-14-17(18-4-2-3-5-19(18)25-14)10-11-23-21(26)16-8-6-15(7-9-16)20-12-22-13-24-20/h2-9,12-13,25H,10-11H2,1H3,(H,22,24)(H,23,26)
SMILES Code
CC1=C(CCNC(C2=CC=C(C3=CNC=N3)C=C2)=O)C4=CC=CC=C4N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
344.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Amaradhi R, Mohammed S, Banik A, Franklin R, Dingledine R, Ganesh T. Second-
Generation Prostaglandin Receptor EP2 Antagonist, TG8-260, with High Potency,
Selectivity, Oral Bioavailability, and Anti-Inflammatory Properties. ACS
Pharmacol Transl Sci. 2022 Jan 25;5(2):118-133. doi: 10.1021/acsptsci.1c00255.
PMID: 35187419; PMCID: PMC8844972.
2: Rojas A, Amaradhi R, Banik A, Jiang C, Abreu-Melon J, Wang S, Dingledine R,
Ganesh T. A Novel Second-Generation EP2 Receptor Antagonist Reduces
Neuroinflammation and Gliosis After Status Epilepticus in Rats.
Neurotherapeutics. 2021 Apr;18(2):1207-1225. doi: 10.1007/s13311-020-00969-5.
Epub 2021 Jan 6. PMID: 33410110; PMCID: PMC8423966.
3: Rawat V, Eastman CL, Amaradhi R, Banik A, Fender JS, Dingledine RJ,
D'Ambrosio R, Ganesh T. Temporal Expression of Neuroinflammatory and Oxidative
Stress Markers and Prostaglandin E2 Receptor EP2 Antagonist Effect in a Rat
Model of Epileptogenesis. ACS Pharmacol Transl Sci. 2022 Dec 8;6(1):128-138.
doi: 10.1021/acsptsci.2c00189. PMID: 36654746; PMCID: PMC9841781.
