CA4+ is a Cationic Iodinated Imaging Contrast Agent. CA+ is useful for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage. Contrast enhanced CT (CECT) using CA4+ reveals significantly greater agent uptake of CA4+ in articular cartilage compared to similar anionic or nonionic agents, and CA4+ uptake follows Donnan Equilibrium. The CA4+ CECT attenuation obtained from imaging ex vivo human hip cartilage correlates with the glycosaminoglycan (GAG) content, equilibrium modulus, and coefficient of friction: key indicators of cartilage functional performance and osteoarthritis stage. Finally, preliminary toxicity studies in a rat model show no adverse events and a pharmacokinetics study documents a peak plasma concentration at 30 minutes after dosing with the agent no longer present in vivo at 96 hours via excretion in the urine.
MedKoo Cat#: 556347
Name: CA+ HCl
CAS#: 2111832-99-4 (HCl)
Chemical Formula: C27H36Cl4I6N10O6
Exact Mass:
Molecular Weight: 1499.88
Elemental Analysis: C, 21.62; H, 2.42; Cl, 9.45; I, 50.77; N, 9.34; O, 6.40
The following data is based on the product molecular weight 1,499.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
