Atirmociclib, also kn own as PF-07220060 is a novel potent oral CDK4-selective inhibitor. It exhibits potent inhibitory activity with dissociation constants (Ki) of 0.6 nM for the CDK4/Cyclin D1 complex and 13.9 nM for the CDK6/Cyclin D3 complex. Its mechanism involves inhibiting the CDK4/Cyclin D complex, thereby preventing phosphorylation of the retinoblastoma (Rb) protein, leading to cell cycle arrest in the G1 phase and potential antineoplastic effects.
MedKoo Cat#: 207196
Name: Atirmociclib
CAS#: 2380321-51-5
Chemical Formula: C22H27ClFN5O3
Exact Mass: 463.1786
Molecular Weight: 463.94
Elemental Analysis: C, 56.96; H, 5.87; Cl, 7.64; F, 4.10; N, 15.10; O, 10.35
The following data is based on the product molecular weight 463.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
