DDO-02005 is a potent and selective inhibitor of the Kv1.5 potassium channel, exhibiting an IC₅₀ of 0.72 μM. In vivo studies have demonstrated its efficacy in suppressing atrial fibrillation (AF) in a CaCl₂-acetylcholine-induced AF rat model and mitigating arrhythmias triggered by aconitine. Pharmacokinetic profiling in Sprague-Dawley rats revealed that, following intravenous administration at 1 mg/kg, DDO-02005 has a half-life of 3.23 ± 1.07 hours, a Cₘₐₓ of 90.23 ± 28.83 μg/L, and an AUC₀–ₜ of 178.42 ± 39.33 μg·h/L. Oral administration at 1.25 mg/kg resulted in a prolonged half-life of 6.25 ± 2.40 hours but significantly lower bioavailability, with a Cₘₐₓ of 1.27 ± 0.40 μg/L and an AUC₀–ₜ of 4.41 ± 0.69 μg·h/L, indicating poor oral absorption.
MedKoo Cat#: 124040
Name: DDO-02005 HCl
CAS#: 1186049-44-4 (2HCl)
Chemical Formula: C21H27Cl2N3O2
Exact Mass: 0.0000
Molecular Weight: 424.37
Elemental Analysis: C, 59.44; H, 6.41; Cl, 16.71; N, 9.90; O, 7.54
The following data is based on the product molecular weight 424.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
