Synonym
L-Tyrosinol hydrochloride; L-Tyrosinol HCl; L Tyrosinol; L-Tyrosinol
IUPAC/Chemical Name
4-(2-amino-3-hydroxypropyl)phenol hydrochloride
InChi Key
PNGCRFWYSRUQTB-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13NO2.ClH/c10-8(6-11)5-7-1-3-9(12)4-2-7;/h1-4,8,11-12H,5-6,10H2;1H
SMILES Code
C1=CC(=CC=C1CC(CO)N)O.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
203.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: KARRER P, PORTMANN P, SUTER M. L-Valinol und L-Tyrosinol [L-valinol and
L-tyrosinol]. Helv Chim Acta. 1949;32(3):1156. German. doi:
10.1002/hlca.19490320374. PMID: 18129602.
2: Descôteaux C, Leblanc V, Brasseur K, Gupta A, Asselin E, Bérubé G. Synthesis
of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell
lines. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7388-92. doi:
10.1016/j.bmcl.2010.10.039. Epub 2010 Oct 21. PMID: 21051231.
3: Zhou Y, Wei W, Cui F, Yan Z, Sun Y, Ren J, Qu X. Construction of a chiral
artificial enzyme used for enantioselective catalysis in live cells. Chem Sci.
2020 Sep 23;11(41):11344-11350. doi: 10.1039/d0sc03082a. PMID: 34094377; PMCID:
PMC8162767.
4: Zhang H, He H, Jiang X, Xia Z, Wei W. Preparation and Characterization of
Chiral Transition-Metal Dichalcogenide Quantum Dots and Their Enantioselective
Catalysis. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30680-30688. doi:
10.1021/acsami.8b10594. Epub 2018 Aug 28. PMID: 30113158.
5: Nie L, Zhang H, Kong W, Kong RM, Zhang ES, Li J, Zhao Y, Qu F. Integrating a
Copper-Histidine Brace in a Mimetic Nanozyme Streamlines the Tyrosinase
Recognition Moiety to Achieve Chiral Differentiation. Anal Chem. 2024 Aug
13;96(32):13158-13165. doi: 10.1021/acs.analchem.4c01966. Epub 2024 Jul 30.
PMID: 39078164.
6: Landau O, Wasserman L, Deutsch AA, Reiss R, Panet H, Novogrodsky A,
Nordenberg J. Amino acid alcohols: growth inhibition and induction of
differentiated features in melanoma cells. Cancer Lett. 1993 May 14;69(3):203-8.
doi: 10.1016/0304-3835(93)90176-a. PMID: 8099846.
7: Jessen HJ, Barbaras D, Hamburger M, Gademann K. Total synthesis and
neuritotrophic activity of farinosone C and derivatives. Org Lett. 2009 Aug
6;11(15):3446-9. doi: 10.1021/ol901277q. PMID: 19586047.
8: Gilabert MA, Fenoll LG, García-Molina F, García-Ruiz PA, Tudela J, García-
Cánovas F, Rodríguez-López JN. Stereospecificity of horseradish peroxidase. Biol
Chem. 2004 Dec;385(12):1177-84. doi: 10.1515/BC.2004.152. PMID: 15653431.
9: Page P, Bradley M, Walters I, Teague S. Solid-Phase Synthesis of Tyrosine
Peptide Aldehydes. Analogues of (S)-MAPI. J Org Chem. 1999 Feb 5;64(3):794-799.
doi: 10.1021/jo981546v. PMID: 11674148.