Synonym
CMLD-2; CMLD2; CMLD 2; MLS000879470; SMR000465530;
IUPAC/Chemical Name
5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one
InChi Key
PROGRNRRJJYCNX-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H31NO6/c1-35-22-13-11-21(12-14-22)23(17-27(33)32-15-7-8-16-32)29-25(36-2)19-26(37-3)30-24(18-28(34)38-31(29)30)20-9-5-4-6-10-20/h4-6,9-14,18-19,23H,7-8,15-17H2,1-3H3
SMILES Code
O=C1C=C(C2=CC=CC=C2)C3=C(OC)C=C(OC)C(C(C4=CC=C(OC)C=C4)CC(N5CCCC5)=O)=C3O1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
513.59
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Allegri L, Baldan F, Roy S, Aubé J, Russo D, Filetti S, Damante G. The HuR
CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid
cancer cells. Sci Rep. 2019 May 14;9(1):7374. doi: 10.1038/s41598-019-43894-0.
PMID: 31089242; PMCID: PMC6517587.
2: Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD,
Herman T, Ramesh R, Munshi A. HuR-targeted small molecule inhibitor exhibits
cytotoxicity towards human lung cancer cells. Sci Rep. 2017 Aug 30;7(1):9694.
doi: 10.1038/s41598-017-07787-4. PMID: 28855578; PMCID: PMC5577245.
3: Kunder N, de la Peña JB, Lou TF, Chase R, Suresh P, Lawson J, Shukla T, Black
B, Campbell ZT. The RNA-Binding Protein HuR Is Integral to the Function of
Nociceptors in Mice and Humans. J Neurosci. 2022 Dec 7;42(49):9129-9141. doi:
10.1523/JNEUROSCI.1630-22.2022. Epub 2022 Oct 21. PMID: 36270801; PMCID:
PMC9761683.
