MedKoo Cat#: 532475 | Name: PNU109291

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNU109291 is a potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

Chemical Structure

PNU109291
PNU109291
CAS#187665-60-7

Theoretical Analysis

MedKoo Cat#: 532475

Name: PNU109291

CAS#: 187665-60-7

Chemical Formula: C24H31N3O3

Exact Mass: 409.2365

Molecular Weight: 409.53

Elemental Analysis: C, 70.39; H, 7.63; N, 10.26; O, 11.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PNU109291; PNU 109291; PNU-109291.
IUPAC/Chemical Name
(1S)-1-{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl}-N-methyl-3,4-dihydro-1H-2-benzopyran-6-carboxamide
InChi Key
UDLSEQDYARNKTL-QHCPKHFHSA-N
InChi Code
InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m0/s1
SMILES Code
O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(OC)C=C4)CC3)=C1)NC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 409.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Watts SW, Darios ES, Seitz BM, Thompson JM. 5-HT is a potent relaxant in rat superior mesenteric veins. Pharmacol Res Perspect. 2015 Feb;3(1):e00103. doi: 10.1002/prp2.103. Epub 2015 Jan 5. PubMed PMID: 25692021; PubMed Central PMCID: PMC4317234. 2: Jeong HJ, Mitchell VA, Vaughan CW. Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn. Br J Pharmacol. 2012 Mar;165(6):1956-65. doi: 10.1111/j.1476-5381.2011.01685.x. PubMed PMID: 21950560; PubMed Central PMCID: PMC3372843.