Synonym
Fosquidone; GR63178A
IUPAC/Chemical Name
benzyl (14-methyl-8,13-dioxo-5,8,13,14-tetrahydrobenzo[5,6]isoindolo[2,1-b]isoquinolin-9-yl) hydrogen phosphate
InChi Key
UXTSQCOOUJTIAC-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H22NO6P/c1-17-20-11-6-5-10-19(20)14-29-15-22-25(26(17)29)27(30)21-12-7-13-23(24(21)28(22)31)35-36(32,33)34-16-18-8-3-2-4-9-18/h2-13,15,17H,14,16H2,1H3,(H,32,33)
SMILES Code
O=P(OC1=C(C2=CC=C1)C(C3=CN4CC5=C(C=CC=C5)C(C)C4=C3C2=O)=O)(OCC6=CC=CC=C6)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
499.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kaye SB, Wanders J, Clavel M, Verweij J, Piccart MJ, Smyth JF, Ten Bokkel Huinink WW, Wagener DJ, Judson IR, Cavalli F. Phase II trials of fosquidone (GR63178A) in carcinoma of the breast, head and neck, ovary and melanoma. Ann Oncol. 1992 May;3(5):406-8. PubMed PMID: 1616895.
2: Planting AS, van der Burg ME, Stoter G, Beranek P, Verweij J. Phase I study of intravenous fosquidone (GR63178A-NSC D611615) using a three times a week schedule. Clin Oncol (R Coll Radiol). 1992 May;4(3):171-3. PubMed PMID: 1586634.
3: Kaye SB, Brampton M, Harper P, Smyth J, Kerr DJ, Gore M, Green JA, Gilby E, Crawford SM, Rustin GJ. Phase II trials of fosquidone, (GR63178A), in colorectal, renal and non-small cell lung cancer. CRC Phase II Clinical Trials Committee. Br J Cancer. 1992 Apr;65(4):624-5. PubMed PMID: 1314072; PubMed Central PMCID: PMC1977569.
