SGC-PI5P4Kγ/MYLK4-1 | CAS# | SGC-PI5P4Kγ/MYLK4-1 Negative Control

MedKoo Cat#: 130596 | Name: SGC-PI5P4Kγ/MYLK4-1N

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGC-PI5P4Kγ/MYLK4-1N is a negative control compound of SGC-PI5P4Kγ/MYLK4-1. PI5P4Kγ is an understudied human lipid kinase with described roles in inflammation, T cell activation, autophagy regulation, immunity, heart failure, and multiple cancers. MYLK4 is also an understudied human kinase.

Chemical Structure

SGC-PI5P4Kγ/MYLK4-1N

CAS#SGC-PI5P4Kγ/MYLK4-1

Theoretical Analysis

MedKoo Cat#: 130596

Name: SGC-PI5P4Kγ/MYLK4-1N

CAS#: SGC-PI5P4Kγ/MYLK4-1

Chemical Formula: C20H18N4

Exact Mass: 314.1531

Molecular Weight: 314.39

Elemental Analysis: C, 76.41; H, 5.77; N, 17.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

SGC-PI5P4Kγ/MYLK4-1

Synonym

SGC-PI5P4Kgamma/MYLK4-1N, SGC-PI5P4Kappagamma/MYLK4-1N, SGC-PI5P4Kγ/MYLK4 1N, SGC-PI5P4Kgamma/MYLK4 1N, SGC-PI5P4Kappagamma/MYLK4 1N

IUPAC/Chemical Name

11-(Cyclopropylethynyl)-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine

InChi Key

OGBQYRNSVJVXIQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H18N4/c21-20-22-11-14-2-1-3-17-18(19(14)24-20)15-10-13(7-6-12-4-5-12)8-9-16(15)23-17/h8-12,23H,1-5H2,(H2,21,22,24)

SMILES Code

NC1=NC=C(CCC2)C(C3=C2NC4=C3C=C(C#CC5CC5)C=C4)=N1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 314.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Ji W, Wang ES, Manz TD, Jiang J, Donovan KA, Abulaiti X, Fischer ES, Cantley LC, Zhang T, Gray NS. Development of potent and selective degraders of PI5P4Kγ. Eur J Med Chem. 2023 Feb 5;247:115027. doi: 10.1016/j.ejmech.2022.115027. Epub 2022 Dec 24. PMID: 36584631; PMCID: PMC10150581. 2. Boffey HK, Rooney TPC, Willems HMG, Edwards S, Green C, Howard T, Ogg D, Romero T, Scott DE, Winpenny D, Duce J, Skidmore J, Clarke JH, Andrews SP. Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem. 2022 Feb 24;65(4):3359-3370. doi: 10.1021/acs.jmedchem.1c01819. Epub 2022 Feb 11. PMID: 35148092; PMCID: PMC9097471. 3. Zheng L, Conner SD. PI5P4Kγ functions in DTX1-mediated Notch signaling. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1983-E1990. doi: 10.1073/pnas.1712142115. Epub 2018 Feb 12. PMID: 29440432; PMCID: PMC5834675. 4. Won K, Kim D, Hwang I, Lee HK, Oh JD. Genome-wide association studies on collagen contents trait for meat quality in Hanwoo. J Anim Sci Technol. 2023 Mar;65(2):311-323. doi: 10.5187/jast.2022.e110. Epub 2023 Mar 31. PMID: 37093907; PMCID: PMC10119448. 5. Aytekin İ, Bayraktar M, Sakar ÇM, Ünal İ. Association between MYLK4 gene polymorphism and growth traits at different age stages in Anatolian black cattle. Anim Biotechnol. 2020 Dec;31(6):555-560. doi: 10.1080/10495398.2020.1823402. Epub 2020 Sep 24. PMID: 32967525. 6. Shi SY, Li LJ, Zhang ZJ, Wang EY, Wang J, Xu JW, Liu HB, Wen YF, He H, Lei CZ, Chen H, Huang YZ. Copy number variation of MYLK4 gene and its growth traits of Capra hircus (goat). Anim Biotechnol. 2020 Dec;31(6):532-537. doi: 10.1080/10495398.2019.1635137. Epub 2019 Jul 7. PMID: 31280665. 7. Zheng L, Zhang GM, Dong YP, Wen YF, Dong D, Lei CZ, Qi XL, Chen H, Huo LJ, Huang YZ. Genetic Variant of MYLK4 Gene and its Association with Growth Traits in Chinese Cattle. Anim Biotechnol. 2019 Jan;30(1):30-35. doi: 10.1080/10495398.2018.1426594. Epub 2018 Mar 14. PMID: 29540101.