NSD2 Inhibitor 15a | CAS# | NSD2 Inhibitor

MedKoo Cat#: 130572 | Name: NSD2 Inhibitor 15a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSD2 Inhibitor 15a is a novel, oral, potent NSD2 inhibitor. It displays significant antitumor efficacy with desirable safety profile in the multiple myeloma xenograft mice models.

Chemical Structure

NSD2 Inhibitor 15a

CAS#NSD2 Inhibitor 15a

Theoretical Analysis

MedKoo Cat#: 130572

Name: NSD2 Inhibitor 15a

CAS#: NSD2 Inhibitor 15a

Chemical Formula: C18H14ClN3O3

Exact Mass: 355.0724

Molecular Weight: 355.78

Elemental Analysis: C, 60.77; H, 3.97; Cl, 9.96; N, 11.81; O, 13.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2604513-16-6

Synonym

NSD2-Inhibitor-15a, NSD2 In 15a, NSD2-In-15a

IUPAC/Chemical Name

N-(3-((7-Chloro-5,8-dioxo-5,8-dihydroquinolin-6-yl)amino)bicyclo[1.1.1]pentan-1-yl)but-2-ynamide

InChi Key

XLARJZRINWFNRT-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14ClN3O3/c1-2-4-11(23)21-17-7-18(8-17,9-17)22-14-12(19)16(25)13-10(15(14)24)5-3-6-20-13/h3,5-6,22H,7-9H2,1H3,(H,21,23)

SMILES Code

CC#CC(NC1(C2)CC2(NC(C(C3=C4N=CC=C3)=O)=C(Cl)C4=O)C1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 355.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Tang H, Yu A, Xing L, Chen X, Ding H, Yang H, Song Z, Shi Q, Geng M, Huang X, Zhang A. Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors. J Med Chem. 2023 Jan 26;66(2):1634-1651. doi: 10.1021/acs.jmedchem.2c01920. Epub 2023 Jan 15. PMID: 36642961.