HDAC8 PROTAC CT-4 | CAS# | HDAC8 Degrader

MedKoo Cat#: 130548 | Name: HDAC8 PROTAC CT-4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HDAC8 PROTAC CT-4 is a novel potent HDAC8 degrader. It induces cell death via apoptosis and shows anti-migration activity in a Triple Negative Breast Cancer cell line and anti-proliferative activity against T-cell leukemia cells.

Chemical Structure

HDAC8 PROTAC CT-4

CAS#HDAC8 PROTAC CT-4

Theoretical Analysis

MedKoo Cat#: 130548

Name: HDAC8 PROTAC CT-4

CAS#: HDAC8 PROTAC CT-4

Chemical Formula: C37H41N5O9

Exact Mass: 699.2904

Molecular Weight: 699.76

Elemental Analysis: C, 63.51; H, 5.91; N, 10.01; O, 20.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HDAC8 PROTAC CT 4, HDAC8 PROTAC CT4

IUPAC/Chemical Name

3-((4-((8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)carbamoyl)benzyl)oxy)-N-hydroxy-4-methoxybenzamide

InChi Key

ARLOQCPNXYNVDU-UHFFFAOYSA-N

InChi Code

InChI=1S/C37H41N5O9/c1-50-29-17-15-25(34(45)41-49)21-30(29)51-22-23-11-13-24(14-12-23)33(44)39-20-7-5-3-2-4-6-19-38-27-10-8-9-26-32(27)37(48)42(36(26)47)28-16-18-31(43)40-35(28)46/h8-15,17,21,28,38,49H,2-7,16,18-20,22H2,1H3,(H,39,44)(H,41,45)(H,40,43,46)

SMILES Code

O=C(NO)C1=CC=C(OC)C(OCC2=CC=C(C(NCCCCCCCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)C=C2)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 699.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zhao C, Chen D, Suo F, Setroikromo R, Quax WJ, Dekker FJ. Discovery of highly potent HDAC8 PROTACs with anti-tumor activity. Bioorg Chem. 2023 Jul;136:106546. doi: 10.1016/j.bioorg.2023.106546. Epub 2023 Apr 17. PMID: 37098288.