Nek2 inhibitor V8 is a novel potent inhibitor of NIMA Related Kinase 2 (Nek2) kinase (IC50 = 2.4±0.2µM). It attenuates pAkt/PI3 Kinase signaling and proliferative and migratory phenotypes of highly aggressive human MDA-MB-231 breast and A549 lung cancer cell lines.
MedKoo Cat#: 130542
Name: Nek2 inhibitor V8
CAS#: Nek2 inhibitor V8
Chemical Formula: C14H16BrN3O3S
Exact Mass: 385.0096
Molecular Weight: 386.26
Elemental Analysis: C, 43.53; H, 4.18; Br, 20.69; N, 10.88; O, 12.43; S, 8.30
The following data is based on the product molecular weight 386.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
