Mosnodenvir, also known as JNJ-1802, is an oral, first-in-class DENV (NS3-NS4B) inhibitor. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Viral RNA suppression to below the limit of detection was achieved at concentrations of >1.6 nM, with a median concentration exhibiting 50% of maximal inhibitory effect (IC50) of 1.23x10-02 nM and 1.28x10-02 nM for the DENV-2/RL and DENV-2/16681 strains, respectively. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice.
MedKoo Cat#: 130537
Name: Mosnodenvir
CAS#: 2043343-94-6
Chemical Formula: C26H22ClF3N2O6S
Exact Mass: 582.0839
Molecular Weight: 582.98
Elemental Analysis: C, 53.57; H, 3.80; Cl, 6.08; F, 9.78; N, 4.81; O, 16.47; S, 5.50
The following data is based on the product molecular weight 582.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
