MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 130527 | Name: NSC-87877 disodium
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively). NSC-87877 shows effective growth inhibition and induction of apoptosis in NB cell lines. In an intrarenal mouse model of NB, NSC-87877 treatment results in decreased tumor growth and increased p53 and p38 activity. DUSP26 inhibition with NSC-87877 is an effective strategy to induce NB cell cytotoxicity in vitro and in vivo through activation of the p53 and p38 mitogen-activated protein kinase (MAPK) tumor-suppressor pathways.

Chemical Structure

NSC-87877 disodium
NSC-87877 disodium
CAS#56932-43-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 130527

Name: NSC-87877 disodium

CAS#: 56932-43-5 (sodium)

Chemical Formula: C19H11N3Na2O7S2

Exact Mass: 0.0000

Molecular Weight: 503.41

Elemental Analysis: C, 45.33; H, 2.20; N, 8.35; Na, 9.13; O, 22.25; S, 12.74

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
56990-57-9 (free acid) 56932-43-5 (sodium)
Synonym
NSC 87877 disodium, NSC87877 disodium, NSC87877, NSC 87877, NSC-87877, NSC.87877
IUPAC/Chemical Name
Disodium 8-hydroxy-7-[(6-sulfonatonaphthalen-2-yl)diazenyl]quinoline-5-sulfonate
InChi Key
IFVGQKHFUZRWNA-ZPZFBZIMSA-L
InChi Code
InChI=1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,23H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-21+;;
SMILES Code
O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)([O-])=O)C=CC4=C3)=C1)([O-])=O.[Na+].[Na+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 503.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. PMID: 16717135. 2. Zhong C, Xie T, Chen L, Zhong X, Li X, Cai X, Chen K, Lan S. Immune depletion of the methylated phenotype of colon cancer is closely related to resistance to immune checkpoint inhibitors. Front Immunol. 2022 Sep 8;13:983636. doi: 10.3389/fimmu.2022.983636. PMID: 36159794; PMCID: PMC9492852. 3. Watkins RD, Buckarma EH, Tomlinson JL, McCabe CE, Yonkus JA, Werneburg NW, Bayer RL, Starlinger PP, Robertson KD, Wang C, Gores GJ, Smoot RL. SHP2 inhibition enhances Yes-associated protein-mediated liver regeneration in murine partial hepatectomy models. JCI Insight. 2022 Aug 8;7(15):e159930. doi: 10.1172/jci.insight.159930. PMID: 35763355; PMCID: PMC9462473. 4. Sigaud R, Dussault N, Berenguer-Daizé C, Vellutini C, Benyahia Z, Cayol M, Parat F, Mabrouk K, Vázquez R, Riveiro ME, Metellus P, Ouafik L. Role of the Tyrosine Phosphatase SHP-2 in Mediating Adrenomedullin Proangiogenic Activity in Solid Tumors. Front Oncol. 2021 Oct 8;11:753244. doi: 10.3389/fonc.2021.753244. PMID: 34692535; PMCID: PMC8531523. 5. Huda S, Cao M, De Rosa A, Woodhall M, Rodriguez Cruz PM, Cossins J, Maestri M, Ricciardi R, Evoli A, Beeson D, Vincent A. SHP2 inhibitor protects AChRs from effects of myasthenia gravis MuSK antibody. Neurol Neuroimmunol Neuroinflamm. 2019 Dec 12;7(1):e645. doi: 10.1212/NXI.0000000000000645. PMID: 31831571; PMCID: PMC6935836. 6. Raghav PK, Singh AK, Gangenahalli G. Stem cell factor and NSC87877 combine to enhance c-Kit mediated proliferation of human megakaryoblastic cells. PLoS One. 2018 Nov 2;13(11):e0206364. doi: 10.1371/journal.pone.0206364. Erratum in: PLoS One. 2018 Dec 28;13(12):e0210133. PMID: 30388134; PMCID: PMC6214509. 7. Yin H, Huang J, Cao X, Wang ZX, Cao J, Hu Y, Luo J, Tan YJ, Chen TH, Chen CY, Xie H. Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Facilitates CD31hiEndomucinhi Blood Vessel and Bone Formation in Ovariectomized Mice. Cell Physiol Biochem. 2018;50(3):1068-1083. doi: 10.1159/000494531. Epub 2018 Oct 24. PMID: 30355920. 8. Tsutsumi R, Ran H, Neel BG. Off-target inhibition by active site-targeting SHP2 inhibitors. FEBS Open Bio. 2018 Aug 1;8(9):1405-1411. doi: 10.1002/2211-5463.12493. Erratum in: FEBS Open Bio. 2019 Dec;9(12):2174. PMID: 30186742; PMCID: PMC6120237. 9. Ding X, Yang W, Liu XD, Yang X, Wang HM, Tai J. Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K. Neuroscience. 2018 Aug 10;385:102-120. doi: 10.1016/j.neuroscience.2018.06.013. Epub 2018 Jun 15. PMID: 29909075. 10. Dayot S, Speisky D, Couvelard A, Bourgoin P, Gratio V, Cros J, Rebours V, Sauvanet A, Bedossa P, Paradis V, Ruszniewski P, Couvineau A, Voisin T. In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma. Oncotarget. 2018 Jan 9;9(6):6952-6967. doi: 10.18632/oncotarget.24084. PMID: 29467942; PMCID: PMC5805528. 11. Ding G, Fei J, Wang J, Xie Y, Li R, Gong N, Lv Y, Yu C, Zou Z. Fimbriatols A-J, Highly Oxidized ent-Kaurane Diterpenoids from Traditional Chinese Plant Flickingeria fimbriata (B1.) Hawkes. Sci Rep. 2016 Aug 3;6:30560. doi: 10.1038/srep30560. PMID: 27484744; PMCID: PMC4971462. 12. Donaubauer EM, Law NC, Hunzicker-Dunn ME. Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3. J Biol Chem. 2016 Sep 9;291(37):19701-12. doi: 10.1074/jbc.M116.733972. Epub 2016 Jul 15. PMID: 27422819; PMCID: PMC5016702. 13. Jung S, Nah J, Han J, Choi SG, Kim H, Park J, Pyo HK, Jung YK. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia. J Neurochem. 2016 Jun;137(5):770-81. doi: 10.1111/jnc.13597. Epub 2016 Mar 17. PMID: 26924229. 14. Shi Y, Ma IT, Patel RH, Shang X, Chen Z, Zhao Y, Cheng J, Fan Y, Rojas Y, Barbieri E, Chen Z, Yu Y, Jin J, Kim ES, Shohet JM, Vasudevan SA, Yang J. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. doi: 10.1038/cddis.2015.207. PMID: 26247726; PMCID: PMC4558500. 15. Zhou RP, Deng MT, Chen LY, Fang N, Du C, Chen LP, Zou YQ, Dai JH, Zhu ML, Wang W, Lin SJ, Liu RH, Luo J. Shp2 regulates chlorogenic acid-induced proliferation and adipogenic differentiation of bone marrow-derived mesenchymal stem cells in adipogenesis. Mol Med Rep. 2015 Jun;11(6):4489-95. doi: 10.3892/mmr.2015.3285. Epub 2015 Jan 30. PMID: 25634525. 16. Ding X, Cai J, Li S, Liu XD, Wan Y, Xing GG. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiol Dis. 2015 Jan;73:428-51. doi: 10.1016/j.nbd.2014.10.025. Epub 2014 Nov 8. PMID: 25447233. 17. Lee KA, Bae EA, Song YC, Kim EK, Lee YS, Kim TG, Kang CY. A multimeric carcinoembryonic antigen signal inhibits the activation of human T cells by a SHP-independent mechanism: a potential mechanism for tumor-mediated suppression of T-cell immunity. Int J Cancer. 2015 Jun 1;136(11):2579-87. doi: 10.1002/ijc.29314. Epub 2014 Nov 21. PMID: 25379865. 18. Luo Q, Sun Y, Gong FY, Liu W, Zheng W, Shen Y, Hua ZC, Xu Q. Blocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice. Br J Pharmacol. 2014 Apr;171(7):1706-21. doi: 10.1111/bph.12565. PMID: 24372081; PMCID: PMC3966750. 19. Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse SM, Philippe M, Benzakour O. The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner. Blood. 2012 Dec 13;120(25):5073-83. doi: 10.1182/blood-2012-05-429183. Epub 2012 Oct 12. PMID: 23065156. 20. Stephan MT, Stephan SB, Bak P, Chen J, Irvine DJ. Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. Biomaterials. 2012 Aug;33(23):5776-87. doi: 10.1016/j.biomaterials.2012.04.029. Epub 2012 May 15. PMID: 22594972; PMCID: PMC3395588.