MedKoo Cat#: 130524 | Name: SYK-85

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SYK-85 is a SHP2 inhibitor. It targets the SHP2-PTP catalytic and allosteric sites (IC50 value of 0.32 ± 0.03 μmol/L).

Chemical Structure

SYK-85
SYK-85
CAS#SYK-85

Theoretical Analysis

MedKoo Cat#: 130524

Name: SYK-85

CAS#: SYK-85

Chemical Formula: C19H16N2O5S

Exact Mass: 384.0780

Molecular Weight: 384.41

Elemental Analysis: C, 59.37; H, 4.20; N, 7.29; O, 20.81; S, 8.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SYK 85, SYK85
IUPAC/Chemical Name
Ethyl (E)-5-(furan-2-yl)-2-(furan-2-ylmethylene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
InChi Key
CZFMMKNXNCUEMU-GXDHUFHOSA-N
InChi Code
InChI=1S/C19H16N2O5S/c1-3-24-18(23)15-11(2)20-19-21(16(15)13-7-5-9-26-13)17(22)14(27-19)10-12-6-4-8-25-12/h4-10,16H,3H2,1-2H3/b14-10+
SMILES Code
O=C(C1=C(C)N=C(S/C(C2=O)=C/C3=CC=CO3)N2C1C4=CC=CO4)OCC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 384.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Song Y, Zhao M, Wu Y, Yu B, Liu HM. A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors. Acta Pharm Sin B. 2021 Mar;11(3):750-762. doi: 10.1016/j.apsb.2020.10.021. Epub 2020 Oct 31. PMID: 33777680; PMCID: PMC7982506.