Synonym
Pyroglutaminyl-seryl-leucinamide; Pyr-ser-leu-NH2; Thyrotropin releasing hormone-AN; Trh-AN;
IUPAC/Chemical Name
(S)-N-((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-hydroxy-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide
InChi Key
WAYDDNVXOHHJSI-GUBZILKMSA-N
InChi Code
InChI=1S/C14H24N4O5/c1-7(2)5-9(12(15)21)17-14(23)10(6-19)18-13(22)8-3-4-11(20)16-8/h7-10,19H,3-6H2,1-2H3,(H2,15,21)(H,16,20)(H,17,23)(H,18,22)/t8-,9-,10-/m0/s1
SMILES Code
CC(C)C[C@@H](C(N)=O)NC([C@H](CO)NC([C@H](CC1)NC1=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
328.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Burov IuV, Vedernikova NN, Borisova IP, Shvachkin IuP, Smirnova AP. [Influence of thyroliberin and its analogs with different hormonal activity on the pharmacological effects of ethanol]. Biull Eksp Biol Med. 1983 May;95(5):42-4. Russian. PubMed PMID: 6405823.
2: Babichev VN, Samsonova VM, Airapetiants MG, Kolomeĭtseva IA, Shvachkin IuP. [Neuroendocrine effect of thyroliberin and its analogs]. Probl Endokrinol (Mosk). 1981 Jul-Aug;27(4):35-8. Russian. PubMed PMID: 6794024.
3: Babichev VN, Samsonova VM, Airapetyants MG, Kolomeitseva IA, Shvachkin YuP, Smirnova AP. Neuroendocrine effects of thyroliberin and its analogs. Neurosci Behav Physiol. 1982 Sep-Oct;12(5):394-7. PubMed PMID: 6820125.
4: Babichev VN, Ignatkov VYa, Shvachkin YuP, Smirnova AP. Comparative analysis of the sensitivity of single neurons of the central nervous system to thyrotropin-releasing hormone and its structural analog. Neurosci Behav Physiol. 1981 Jul-Aug;11(4):385-8. PubMed PMID: 6806677.
5: Samsonova VM, Babichev VN, Shvachkin IuP, Smirnova AP. [Comparative study of the neurotropic and hormonal activity of thyrotropin releasing hormone and its analogs]. Probl Endokrinol (Mosk). 1980 Mar-Apr;26(2):48-52. Russian. PubMed PMID: 6769109.
