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MedKoo Cat#: 130515 | Name: Relacidine B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Relacidine B is a novel non-ribosomal lipopeptide antibiotic, showing promising activity against Gram-negative pathogens.

Chemical Structure

Relacidine B
Relacidine B
CAS#Relacidine B

Theoretical Analysis

MedKoo Cat#: 130515

Name: Relacidine B

CAS#: Relacidine B

Chemical Formula: C78H113N19O19

Exact Mass: 1619.8460

Molecular Weight: 1620.88

Elemental Analysis: C, 57.80; H, 7.03; N, 16.42; O, 18.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Relacidine-B, RelacidineB
IUPAC/Chemical Name
4-Methylhexanoyl-D-Ser-D-Tyr-D-Trp-D-Orn-Orn-Gly-D-Orn-Trp-Thr(1)-Ile-Asn-Ser-Ala-(1)
InChi Key
SLIDJTHNEAILBF-NPAOMGBPSA-N
InChi Code
InChI=1S/C78H113N19O19/c1-7-41(3)23-28-63(102)88-60(39-98)75(112)91-56(32-45-24-26-48(100)27-25-45)70(107)93-57(33-46-36-83-51-18-11-9-16-49(46)51)71(108)90-55(22-15-31-81)69(106)89-53(20-13-29-79)67(104)85-38-64(103)87-54(21-14-30-80)68(105)92-58(34-47-37-84-52-19-12-10-17-50(47)52)73(110)97-66-44(6)116-78(115)43(5)86-74(111)61(40-99)95-72(109)59(35-62(82)101)94-76(113)65(42(4)8-2)96-77(66)114/h9-12,16-19,24-27,36-37,41-44,53-61,65-66,83-84,98-100H,7-8,13-15,20-23,28-35,38-40,79-81H2,1-6H3,(H2,82,101)(H,85,104)(H,86,111)(H,87,103)(H,88,102)(H,89,106)(H,90,108)(H,91,112)(H,92,105)(H,93,107)(H,94,113)(H,95,109)(H,96,114)(H,97,110)/t41?,42-,43-,44+,53-,54+,55+,56+,57+,58-,59-,60+,61-,65-,66-/m0/s1
SMILES Code
O=C([C@@H](NC([C@@H](CCCN)NC(CNC([C@@H](NC([C@@H](CCCN)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3=CC=C(O)C=C3)NC([C@H](NC(CCC(CC)C)=O)CO)=O)=O)=O)=O)CCCN)=O)=O)=O)CC4=CNC5=C4C=CC=C5)N[C@@H]([C@@H](C)OC([C@H](C)NC([C@H](CO)NC([C@@H]6CC(N)=O)=O)=O)=O)C(N[C@H](C(N6)=O)[C@@H](C)CC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,620.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Li Z, Chakraborty P, de Vries RH, Song C, Zhao X, Roelfes G, Scheffers DJ, Kuipers OP. Characterization of two relacidines belonging to a novel class of circular lipopeptides that act against Gram-negative bacterial pathogens. Environ Microbiol. 2020 Dec;22(12):5125-5136. doi: 10.1111/1462-2920.15145. Epub 2020 Jul 20. PMID: 32608161; PMCID: PMC7818431. 2. Li Z, de Vries RH, Chakraborty P, Song C, Zhao X, Scheffers DJ, Roelfes G, Kuipers OP. Novel Modifications of Nonribosomal Peptides from Brevibacillus laterosporus MG64 and Investigation of Their Mode of Action. Appl Environ Microbiol. 2020 Nov 24;86(24):e01981-20. doi: 10.1128/AEM.01981-20. PMID: 32978140; PMCID: PMC7688214.