NT160 is highly potent class-IIa histone deacetylase probe. Radio-labed [18F]-NT160 is a diagnostic tool for positron emission tomography (PET). [18F]-NT160 can cross the blood brain barrier and bind to class-IIa HDACs in vivo. PET imaging with [18F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast images of the brain. [18F]NT160 displayed excellent pharmacokinetic and imaging characteristics: brain uptake is high in gray matter regions, tissue kinetics are appropriate for a 18F-tracer, and specific binding for class-IIa HDACs is demonstrated by self-blockade. Note: This product we are supplying is not radiolabeled.
MedKoo Cat#: 130509
Name: NT160
CAS#: 1418293-40-9 (free base)
Chemical Formula: C21H21F3N4O2
Exact Mass: 418.1617
Molecular Weight: 418.42
Elemental Analysis: C, 60.28; H, 5.06; F, 13.62; N, 13.39; O, 7.65
The following data is based on the product molecular weight 418.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
