WDR5 Inhibitor 262 | CAS# | WDR5 Inhibitor

MedKoo Cat#: 130492 | Name: WDR5 Inhibitor 262

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WDR5 Inhibitor 262 is a highly potent WDR5 inhibitor.

Chemical Structure

WDR5 Inhibitor 262

CAS#WDR5 Inhibitor 262

Theoretical Analysis

MedKoo Cat#: 130492

Name: WDR5 Inhibitor 262

CAS#: WDR5 Inhibitor 262

Chemical Formula: C29H31N7O2

Exact Mass: 509.2539

Molecular Weight: 509.61

Elemental Analysis: C, 68.35; H, 6.13; N, 19.24; O, 6.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

WDR5 Inhibitor-262, WDR5 262, WDR5-262

IUPAC/Chemical Name

(S)-6-(1-(5-(1,3-Dimethyl-1H-pyrazol-4-yl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-4-ethoxynicotinonitrile

InChi Key

NRVDCMIJTOZKGP-IBGZPJMESA-N

InChi Code

InChI=1S/C29H31N7O2/c1-6-38-28-13-27(32-15-22(28)14-30)19(3)36-9-7-23-24(26-17-34(5)33-18(26)2)11-21(12-25(23)29(36)37)16-35-10-8-31-20(35)4/h8,10-13,15,17,19H,6-7,9,16H2,1-5H3/t19-/m0/s1

SMILES Code

N#CC1=CN=C([C@@H](N(CCC2=C3C=C(CN4C=CN=C4C)C=C2C5=CN(C)N=C5C)C3=O)C)C=C1OCC

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 509.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Liu L, Shen L, Ding Z, He M, Li E, Tallarico JA, Jain RK, Wang H. Mechanism of Resistance to the WDR5 Inhibitor in MLL-Rearranged Leukemia. ACS Chem Biol. 2023 Apr 21;18(4):949-958. doi: 10.1021/acschembio.3c00108. Epub 2023 Apr 7. PMID: 37027891.