EGFRL858R/T790M inhibitor 28f is a selective EGFR L858R/T790M inhibitor, exhibiting strong inhibitory activity against EGFR L858R/T790M (IC50 = 3.5 nM) and greater than 368-fold selectivity over EGFR WT (IC50 = 1290 nM), a 6.7-fold improvement over osimertinib, effectively inhibiting downstream signaling pathways and inducing apoptosis in mutant cells.
MedKoo Cat#: 130490
Name: EGFRL858R/T790M inhibitor 28f
CAS#: TBD
Chemical Formula: C28H28FN7O
Exact Mass: 497.2339
Molecular Weight: 497.58
Elemental Analysis: C, 67.59; H, 5.67; F, 3.82; N, 19.71; O, 3.22
The following data is based on the product molecular weight 497.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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