WP1220 is a STAT3 inhibitor. WP1220 is an analog of WP1066 being developed for topical, dermatological conditions. Mycosis Fungoides or MF, the most common variant of CTCL, is a disease with symptomatic, disfiguring skin lesions. STAT3, an oncogenic transcription factor, has been identified as a critical regulator of MF, whereby the activation of STAT3 through phosphorylation (p-STAT3) has been linked to tumor proliferation and suppression of immune responses. Preclinical testing demonstrated that WP1220, a synthetic compound, potently inhibits the activity of p-STAT3 and the growth of CTCL cell lines.
MedKoo Cat#: 127248
Name: WP1220
CAS#: N/A
Chemical Formula: C19H16BrN3O
Exact Mass: 381.0477
Molecular Weight: 382.26
Elemental Analysis: C, 59.70; H, 4.22; Br, 20.90; N, 10.99; O, 4.19
The following data is based on the product molecular weight 382.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
4040.jpg "Enbezotinib")
