(R)-YNT-3708| CAS#2923137-94-2 | OX1R Agonist

MedKoo Cat#: 130489 | Name: (R)-YNT-3708

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-YNT-3708 is an Orexin 1 Receptor (OX1R)-Selective Agonist (EC50 = 7.48 nM for OX1R; OX2R/OX1R EC50 ratio = 22.5), exhibiting antinociceptive and reinforcing effects through the activation of OX1R in mice.

Chemical Structure

(R)-YNT-3708

CAS#2923137-94-2

Theoretical Analysis

MedKoo Cat#: 130489

Name: (R)-YNT-3708

CAS#: 2923137-94-2

Chemical Formula: C35H36N4O6S

Exact Mass: 640.2356

Molecular Weight: 640.76

Elemental Analysis: C, 65.61; H, 5.66; N, 8.74; O, 14.98; S, 5.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

(R) YNT 3708, (R)-YNT 3708, R-YNT-3708, R YNT 3708

IUPAC/Chemical Name

(R,E)-3-(4-Methoxy-3-(N-(8-(2-(3-methoxyphenyl)-N-methylacetamido)-5,6,7,8-tetrahydronaphthalen-2-yl)sulfamoyl)phenyl)-N-(pyridin-4-yl)acrylamide

InChi Key

CUXJBONFEXBSTQ-YTUVCLRASA-N

InChi Code

InChI=1S/C35H36N4O6S/c1-39(35(41)22-25-6-4-8-29(20-25)44-2)31-9-5-7-26-12-13-28(23-30(26)31)38-46(42,43)33-21-24(10-14-32(33)45-3)11-15-34(40)37-27-16-18-36-19-17-27/h4,6,8,10-21,23,31,38H,5,7,9,22H2,1-3H3,(H,36,37,40)/b15-11+/t31-/m1/s1

SMILES Code

O=C(NC1=CC=NC=C1)/C=C/C2=CC=C(OC)C(S(=O)(NC3=CC=C4CCC[C@@H](N(C)C(CC5=CC=CC(OC)=C5)=O)C4=C3)=O)=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 640.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Iio K, Hashimoto K, Nagumo Y, Amezawa M, Hasegawa T, Yamamoto N, Kutsumura N, Takeuchi K, Ishikawa Y, Yamamoto H, Tokuda A, Sato T, Uchida Y, Inoue A, Tanimura R, Yanagisawa M, Nagase H, Saitoh T. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. J Med Chem. 2023 Apr 27;66(8):5453-5464. doi: 10.1021/acs.jmedchem.2c01773. Epub 2023 Apr 12. PMID: 37043436.