Elinafide | LU79553 | CAS#162706-37-8 | DNA intercalator

MedKoo Cat#: 201220 | Name: Elinafide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LU 79553, also known as LU 79553, is a novel DNA intercalator with potent antitumor activity which is highly cytotoxic in vitro with EC50 (concentration required for 50% inhibition of growth) ranging from 2 x 10(-7) to 5 x 10(-10) M. LU-79553 is also a DNA-binding topoisomerase II inhibitor that is particularly effective against human solid tumors that are refractory to other drugs.

Chemical Structure

Elinafide

CAS#162706-37-8,

Theoretical Analysis

MedKoo Cat#: 201220

Name: Elinafide

CAS#: 162706-37-8,

Chemical Formula: C31H28N4O4

Exact Mass: 520.2111

Molecular Weight: 520.58

Elemental Analysis: C, 71.52; H, 5.42; N, 10.76; O, 12.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LU79553; LU 79553; LU-79553; Elinafide

IUPAC/Chemical Name

2-[2-[3-[2-(1,3-dioxobenzo[e]isoindol-2-yl)ethylamino]propylamino]ethyl]benzo[e]isoindole-1,3-dione.

InChi Key

CSAUBGZZOLHVPD-UHFFFAOYSA-N

InChi Code

InChI=1S/C31H28N4O4/c36-28-24-12-10-20-6-1-3-8-22(20)26(24)30(38)34(28)18-16-32-14-5-15-33-17-19-35-29(37)25-13-11-21-7-2-4-9-23(21)27(25)31(35)39/h1-4,6-13,32-33H,5,14-19H2

SMILES Code

O=C(C1=C2C=CC3=CC=CC=C13)N(CCNCCCNCCN(C(C4=C5C=CC6=CC=CC=C46)=O)C5=O)C2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not soluble in water.

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

LU 79553 is a novel bis-naphthalimide which is highly cytotoxic in vitro with EC50 (concentration required for 50% inhibition of growth) ranging from 2 x 10(-7) to 5 x 10(-10) M. A number of studies were conducted to examine its antitumor activity in human xenograft models. Complete regression of MX-1 (mammary carcinoma) xenografts was observed when LU 79553 was administered i.v. daily for 5 doses at 20 mg/kg (2 cycles starting on Days 6 and 20) or every 3 days for 2 doses at 55 mg/kg (2 cycles starting on Days 6 and 13) or every 7 days for 4 doses. Complete regression was also seen in the MX-1 model when tumors were staged at 1-2 g prior to the initiation of treatment. Regressions (complete or partial) were observed in the LX-1 (lung), CX-1 (colon), DLD (colon), and LOX (melanoma) xenograft models. A significant increase in the median survival time of OVCAR-3- (ovarian carcinoma) bearing mice was noted in LU 79553-treated animals (treated/control = 195%). The excellent activity of this compound in such a wide variety of tumor types suggests LU 79553 merits further investigation in clinical trials. see: http://www.ncbi.nlm.nih.gov/pubmed/7867004.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 520.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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