AZ8010 | CAS#N/A | FGFR inhibitor

MedKoo Cat#: 130473 | Name: AZ8010

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ8010, also known as AZ12908010, is an inhibitor of FGFR, completely inhibiting FGFR-1 and significantly inhibiting FGFR-4. AZ8010 shows promise in the treatment of prostate cancer as well as head and neck squamous cell carcinoma.

Chemical Structure

AZ8010

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130473

Name: AZ8010

CAS#: N/A

Chemical Formula: C27H34N4O3

Exact Mass: 462.2631

Molecular Weight: 462.59

Elemental Analysis: C, 70.10; H, 7.41; N, 12.11; O, 10.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AZ8010; AZ 8010; AZ-8010; AZ12908010; AZ 12908010; AZ-12908010

IUPAC/Chemical Name

N-(3-(3,5-dimethoxyphenethyl)-1H-pyrazol-5-yl)-4-(1-ethylpiperidin-4-yl)benzamide

InChi Key

BVJBIYYANCOBPH-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H34N4O3/c1-4-31-13-11-21(12-14-31)20-6-8-22(9-7-20)27(32)28-26-17-23(29-30-26)10-5-19-15-24(33-2)18-25(16-19)34-3/h6-9,15-18,21H,4-5,10-14H2,1-3H3,(H2,28,29,30,32)

SMILES Code

O=C(NC1=CC(CCC2=CC(OC)=CC(OC)=C2)=NN1)C3=CC=C(C4CCN(CC)CC4)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Feng S, Shao L, Yu W, Gavine P, Ittmann M. Targeting fibroblast growth factor receptor signaling inhibits prostate cancer progression. Clin Cancer Res. 2012 Jul 15;18(14):3880-8. doi: 10.1158/1078-0432.CCR-11-3214. Epub 2012 May 9. PMID: 22573348; PMCID: PMC4654778. 2. Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE. A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines. Mol Pharmacol. 2013 Apr;83(4):882-93. doi: 10.1124/mol.112.084111. Epub 2013 Jan 31. PMID: 23371912; PMCID: PMC3608435.