MedKoo Cat#: 130471 | Name: UK4b

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UK4b is an mPGES-1 inhibitor that is effective in both mice and humans and has greater anti-inflammatory and analgesic effects as compared to oxycodone and gabapentin.

Chemical Structure

UK4b
UK4b
CAS#2171000-87-4

Theoretical Analysis

MedKoo Cat#: 130471

Name: UK4b

CAS#: 2171000-87-4

Chemical Formula: C21H25ClN2O4

Exact Mass: 404.1503

Molecular Weight: 404.89

Elemental Analysis: C, 62.30; H, 6.22; Cl, 8.76; N, 6.92; O, 15.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
UK4b
IUPAC/Chemical Name
5-(3-chloro-4-(4-cyclohexylbutoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
InChi Key
WNVDLSYMUWMZRX-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25ClN2O4/c22-17-13-15(12-16-19(25)23-21(27)24-20(16)26)9-10-18(17)28-11-5-4-8-14-6-2-1-3-7-14/h9-10,12-14H,1-8,11H2,(H2,23,24,25,26,27)
SMILES Code
O=C1NC(/C(C(N1)=O)=C\C2=CC=C(OCCCCC3CCCCC3)C(Cl)=C2)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 404.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Stewart MJ, Weaver LM, Ding K, Kyomuhangi A, Loftin CD, Zheng F, Zhan CG. Analgesic effects of a highly selective mPGES-1 inhibitor. Sci Rep. 2023 Feb 27;13(1):3326. doi: 10.1038/s41598-023-30164-3. PMID: 36849491; PMCID: PMC9971260. 2. Ding K, Zhou Z, Hou S, Yuan Y, Zhou S, Zheng X, Chen J, Loftin C, Zheng F, Zhan CG. Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs. Sci Rep. 2018 Mar 26;8(1):5205. doi: 10.1038/s41598-018-23482-4. PMID: 29581541; PMCID: PMC5979965.