MedKoo Cat#: 130470 | Name: STING agonist D61

Description:

WARNING: This product is for research use only, not for human or veterinary use.

STING agonist D61 is a stimulator of interferon gene (STING) agonist that has been found to increase the transcription of IFN-β and proinflammatory cytokine CXCL10. In a CT-26 syngeneic mice-bearing tumor model, STING agonist D61 was found to successfully suppress tumor activity.

Chemical Structure

STING agonist D61
STING agonist D61
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130470

Name: STING agonist D61

CAS#: N/A

Chemical Formula: C29H29F3N8O4

Exact Mass: 610.2264

Molecular Weight: 610.60

Elemental Analysis: C, 57.05; H, 4.79; F, 9.33; N, 18.35; O, 10.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
STING agonist D61
IUPAC/Chemical Name
2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1-(3-((5-(2-(trifluoromethyl)phenyl)oxazol-2-yl)amino)propyl)-1H-benzo[d]imidazole-5-carboxamide
InChi Key
SAIPDXPIJPBWOT-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H29F3N8O4/c1-4-40-21(12-16(2)38-40)26(42)37-27-36-20-13-17(25(33)41)14-22(43-3)24(20)39(27)11-7-10-34-28-35-15-23(44-28)18-8-5-6-9-19(18)29(30,31)32/h5-6,8-9,12-15H,4,7,10-11H2,1-3H3,(H2,33,41)(H,34,35)(H,36,37,42)
SMILES Code
O=C(C1=CC(OC)=C2N(CCCNC3=NC=C(C4=CC=CC=C4C(F)(F)F)O3)C(NC(C5=CC(C)=NN5CC)=O)=NC2=C1)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 610.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chen NN, Zhang H, Zhu QS, Zeng T, Dai W, Zhou YL, Xin GF, Wu BD, Gong SJ, Jiang ZY, You QD, Xu XL. Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.2c02046. Epub ahead of print. PMID: 37027512.