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MedKoo Cat#: 581615 | Name: Deaminocozymase

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deaminocozymase also known as Nicotinamide-hypoxanthine dinucleotide, is a biochemical.

Chemical Structure

Deaminocozymase
Deaminocozymase
CAS#1851-07-6

Theoretical Analysis

MedKoo Cat#: 581615

Name: Deaminocozymase

CAS#: 1851-07-6

Chemical Formula: C21H27N6O15P2+

Exact Mass: 665.1004

Molecular Weight: 665.42

Elemental Analysis: C, 37.91; H, 4.09; N, 12.63; O, 36.07; P, 9.31

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Deaminocozymase; Nicotinamide-hypoxanthine dinucleotide; Desamino-DPN; Deamino-NAD; Deamino DPN; Deamino NAD.
IUPAC/Chemical Name
3-carbamoyl-1-(5-(((((((3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyridin-1-ium
InChi Key
DGVSIBCCYUVRNA-UHFFFAOYSA-O
InChi Code
InChI=1S/C21H26N6O15P2/c22-17(32)9-2-1-3-26(4-9)20-15(30)13(28)10(40-20)5-38-43(34,35)42-44(36,37)39-6-11-14(29)16(31)21(41-11)27-8-25-12-18(27)23-7-24-19(12)33/h1-4,7-8,10-11,13-16,20-21,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37)/p+1
SMILES Code
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5O)O)O)O)O)C(=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 665.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abdul-Awal SM, Hotta CT, Davey MP, Dodd AN, Smith AG, Webb AA. NO-Mediated [Ca2+]cyt Increases Depend on ADP-Ribosyl Cyclase Activity in Arabidopsis. Plant Physiol. 2016 May;171(1):623-31. doi: 10.1104/pp.15.01965. Epub 2016 Mar 1. PubMed PMID: 26932235; PubMed Central PMCID: PMC4854697. 2: Kostyrko VA, Bertsova YV, Serebryakova MV, Baykov AA, Bogachev AV. NqrM (DUF539) Protein Is Required for Maturation of Bacterial Na+-Translocating NADH:Quinone Oxidoreductase. J Bacteriol. 2015 Dec 7;198(4):655-63. doi: 10.1128/JB.00757-15. PubMed PMID: 26644436; PubMed Central PMCID: PMC4751810. 3: Ali TH, Ali NH, Haroun BM, Tantawy AE. Purification and partial characterization of NAD aminohydrolase from Aspergillus oryzae NRRL447. World J Microbiol Biotechnol. 2014 Mar;30(3):819-25. doi: 10.1007/s11274-013-1483-1. Epub 2013 Oct 25. PubMed PMID: 24158390. 4: Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T, Sugawara A, Yonekura H, Okamoto H. Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate. Mol Cell Biochem. 2012 Jul;366(1-2):69-80. doi: 10.1007/s11010-012-1284-0. Epub 2012 Mar 16. PubMed PMID: 22422046. 5: Guérard F, Pétriacq P, Gakière B, Tcherkez G. Liquid chromatography/time-of-flight mass spectrometry for the analysis of plant samples: a method for simultaneous screening of common cofactors or nucleotides and application to an engineered plant line. Plant Physiol Biochem. 2011 Oct;49(10):1117-25. doi: 10.1016/j.plaphy.2011.06.003. Epub 2011 Jun 17. PubMed PMID: 21723140. 6: Johansson FI, Michalecka AM, Møller IM, Rasmusson AG. Oxidation and reduction of pyridine nucleotides in alamethicin-permeabilized plant mitochondria. Biochem J. 2004 May 15;380(Pt 1):193-202. PubMed PMID: 14972026; PubMed Central PMCID: PMC1224159. 7: Küchler M, Decker S, Hörmann F, Soll J, Heins L. Protein import into chloroplasts involves redox-regulated proteins. EMBO J. 2002 Nov 15;21(22):6136-45. PubMed PMID: 12426385; PubMed Central PMCID: PMC137210. 8: Cho KH, Kim YJ. Enzymatic and energetic properties of the aerobic respiratory chain-linked NADH oxidase system in the marine bacterium Pseudomonas nautica. Mol Cells. 2000 Aug 31;10(4):432-6. PubMed PMID: 10987141. 9: Migaud ME, Pederick RL, Bailey VC, Potter BV. Probing Aplysia californica adenosine 5'-diphosphate ribosyl cyclase for substrate binding requirements: design of potent inhibitors. Biochemistry. 1999 Jul 13;38(28):9105-14. PubMed PMID: 10413485. 10: Sauve AA, Munshi C, Lee HC, Schramm VL. The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries. Biochemistry. 1998 Sep 22;37(38):13239-49. PubMed PMID: 9748331. 11: Ziegler M, Jorcke D, Schweiger M. Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase. Biochem J. 1997 Sep 1;326 ( Pt 2):401-5. PubMed PMID: 9291111; PubMed Central PMCID: PMC1218684. 12: Kikonyogo A, Pietruszko R. Cimetidine and other H2-receptor antagonists as inhibitors of human E3 aldehyde dehydrogenase. Mol Pharmacol. 1997 Aug;52(2):267-71. PubMed PMID: 9271349. 13: Mesecar AD, Stoddard BL, Koshland DE Jr. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science. 1997 Jul 11;277(5323):202-6. PubMed PMID: 9211842. 14: Grunwald SK, Ludden PW. NAD-dependent cross-linking of dinitrogenase reductase and dinitrogenase reductase ADP-ribosyltransferase from Rhodospirillum rubrum. J Bacteriol. 1997 May;179(10):3277-83. PubMed PMID: 9150224; PubMed Central PMCID: PMC179107. 15: Oei SL, Griesenbeck J, Buchlow G, Jorcke D, Mayer-Kuckuk P, Wons T, Ziegler M. NAD+ analogs substituted in the purine base as substrates for poly(ADP-ribosyl) transferase. FEBS Lett. 1996 Nov 11;397(1):17-21. PubMed PMID: 8941705. 16: Quinn GB, Trimboli AJ, Prosser IM, Barber MJ. Spectroscopic and kinetic properties of a recombinant form of the flavin domain of spinach NADH: nitrate reductase. Arch Biochem Biophys. 1996 Mar 1;327(1):151-60. PubMed PMID: 8615685. 17: Ralevic V. Modulation by nicotinamide adenine dinucleotide of sympathetic and sensory-motor neurotransmission via P1-purinoceptors in the rat mesenteric arterial bed. Br J Pharmacol. 1995 Apr;114(8):1541-8. PubMed PMID: 7599921; PubMed Central PMCID: PMC1510401. 18: Inageda K, Takahashi K, Tokita K, Nishina H, Kanaho Y, Kukimoto I, Kontani K, Hoshino S, Katada T. Enzyme properties of Aplysia ADP-ribosyl cyclase: comparison with NAD glycohydrolase of CD38 antigen. J Biochem. 1995 Jan;117(1):125-31. PubMed PMID: 7775378. 19: Trimboli AJ, Barber MJ. Assimilatory nitrate reductase: reduction and inhibition by NADH/NAD+ analogs. Arch Biochem Biophys. 1994 Nov 15;315(1):48-53. PubMed PMID: 7979404. 20: Kim UH, Kim MK, Kim JS, Han MK, Park BH, Kim HR. Purification and characterization of NAD glycohydrolase from rabbit erythrocytes. Arch Biochem Biophys. 1993 Aug 15;305(1):147-52. PubMed PMID: 8393643.

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MB5697

MB5697