MMV688845 | CAS#2208962-35-8 | RNA polymerase inhibitor

MedKoo Cat#: 130435 | Name: MMV688845

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MMV688845 is a RNA polymerase inhibitor and is used against nontuberculous mycobacteria, specifically displaying activity against M. abscessus.

Chemical Structure

MMV688845

CAS#2208962-35-8

Theoretical Analysis

MedKoo Cat#: 130435

Name: MMV688845

CAS#: 2208962-35-8

Chemical Formula: C24H25N3O3S

Exact Mass: 435.1617

Molecular Weight: 435.54

Elemental Analysis: C, 66.19; H, 5.79; N, 9.65; O, 11.02; S, 7.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

MMV688845; MMV 688845; MMV-688845

IUPAC/Chemical Name

(R)-N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide

InChi Key

YZLODHPDCSNHTP-HXUWFJFHSA-N

InChi Code

InChI=1S/C24H25N3O3S/c28-23(25-19-9-4-5-10-21(19)27-12-14-30-15-13-27)20(17-18-7-2-1-3-8-18)26-24(29)22-11-6-16-31-22/h1-11,16,20H,12-15,17H2,(H,25,28)(H,26,29)/t20-/m1/s1

SMILES Code

O=C(C1=CC=CS1)N[C@H](CC2=CC=CC=C2)C(NC3=CC=CC=C3N4CCOCC4)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 435.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria. Lang M, Ganapathy US, Mann L, Abdelaziz R, Seidel RW, Goddard R, Sequenzia I, Hoenke S, Schulze P, Aragaw WW, Csuk R, Dick T, Richter A. J Med Chem. 2023 Apr 13;66(7):5079-5098. doi: 10.1021/acs.jmedchem.3c00009. Epub 2023 Mar 31. PMID: 37001025 2. In Vitro Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus. Mann L, Ganapathy US, Abdelaziz R, Lang M, Zimmerman MD, Dartois V, Dick T, Richter A. Microbiol Spectr. 2022 Dec 21;10(6):e0276022. doi: 10.1128/spectrum.02760-22. Epub 2022 Nov 15. PMID: 36377951 Free PMC article. 3. Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity. Mann L, Lang M, Schulze P, Halz JH, Csuk R, Hoenke S, Seidel RW, Richter A. Amino Acids. 2021 Aug;53(8):1187-1196. doi: 10.1007/s00726-021-03044-1. Epub 2021 Jul 14. PMID: 34259925 Free PMC article. 4. Pathogen Box screening for hit identification against Mycobacterium abscessus. Jeong J, Kim G, Moon C, Kim HJ, Kim TH, Jang J. PLoS One. 2018 Apr 26;13(4):e0195595. doi: 10.1371/journal.pone.0195595. eCollection 2018. PMID: 29698397 Free PMC article.