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MedKoo Cat#: 571342 | Name: Astromicin Sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Astromicin Sulfate is an antibiotic with aminoglycoside structure. It may produce depression of neuromuscular function which may cause prolonged paralysis of respiratory muscles, and this is achieved through neuromuscular block.

Chemical Structure

Astromicin Sulfate
Astromicin Sulfate
CAS#72275-67-3 (sulfate)

Theoretical Analysis

MedKoo Cat#: 571342

Name: Astromicin Sulfate

CAS#: 72275-67-3 (sulfate)

Chemical Formula: C17H39N5O14S2

Exact Mass:

Molecular Weight: 601.64

Elemental Analysis: C, 33.94; H, 6.53; N, 11.64; O, 37.23; S, 10.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
55779-06-1 (free base) 72275-67-3 (sulfate)
Synonym
Astromicin Sulfate; A 44747; A44747; A-44747
IUPAC/Chemical Name
L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-, disulfate
InChi Key
TYNZVWXDLOJTIM-QQFWICJTSA-N
InChi Code
InChI=1S/C17H35N5O6.2H2O4S/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18;2*1-5(2,3)4/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3;2*(H2,1,2,3,4)/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+;;/m0../s1
SMILES Code
CO[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@@H]1N(C(CN)=O)C)O)O[C@H]2O[C@H]([C@@H](N)C)CC[C@H]2N)N)O.OS(=O)(O)=O.OS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 601.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu M, Kato M, Hashimoto Y. Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit. Pharmacology. 2001;63(3):142-6. PubMed PMID: 11598419. 2: Ohta T, Hasegawa M. Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglycoside-resistance-encoding genes. Gene. 1993 May 15;127(1):63-9. PubMed PMID: 8486289. 3: Yoneyama H, Okachi R. [Effects of astromicin on a host defence mechanism]. Jpn J Antibiot. 1986 Jun;39(6):1494-503. Japanese. PubMed PMID: 3761562. 4: Dairi T, Ohta T, Hashimoto E, Hasegawa M. Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA. Mol Gen Genet. 1992 Dec;236(1):39-48. PubMed PMID: 1494349. 5: Inouye S, Niizato T, Shomura T, Kitasato I. Nephrotoxicity of dactimicin, a novel pseudo-disaccharide aminoglycoside possessing the N-formimidoyl group, compared with that of astromicin, amikacin and other aminoglycoside antibiotics in animals. Drugs Exp Clin Res. 1989;15(5):189-209. PubMed PMID: 2791871. 6: Kobayashi S, Takai K, Inoue A. [High performance liquid chromatographic determination of astromicin and cefsulodin used in combination in blood samples]. Jpn J Antibiot. 1986 Dec;39(12):3140-7. Japanese. PubMed PMID: 3560432. 7: Moriguchi R, Yamagoshi T, Nemoto S, Naide Y, Suzuki K, Inoue A, Kobayashi S. [Pharmacokinetics of astromicin intravenous drip infusion in patients with renal disorders]. Jpn J Antibiot. 1986 Jun;39(6):1480-6. Japanese. PubMed PMID: 3761561. 8: Suzuki K, Takanashi K, Nagakubo I, Kiyosaki H, Naide Y. [Clinical study of astromicin administered by intravenous drip infusion against chronic complicated urinary tract infections]. Jpn J Antibiot. 1987 Jul;40(7):1299-310. Japanese. PubMed PMID: 3682183. 9: Kobayashi S, Takai K, Masuda S, Inoue A. [High performance liquid chromatographic determination of astromicin and cefoperazone used in combination in blood samples]. Jpn J Antibiot. 1986 Dec;39(12):3148-55. Japanese. PubMed PMID: 3560433. 10: Kawamoto T, Mashimo I, Yamauchi S, Watanabe M. Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography. J Chromatogr. 1984 Feb 10;305(2):373-9. PubMed PMID: 6707164. 11: Uematsu T. Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug. Int J Clin Pharmacol Ther Toxicol. 1993 Dec;31(12):606-10. PubMed PMID: 8314363. 12: Morita M, Hasuda A. [Astromicin sulfate concentration in human prostatic tissue after an intramuscular injection]. Hinyokika Kiyo. 1988 Oct;34(10):1865-8. Japanese. PubMed PMID: 2469325. 13: Endo K. [Neuromuscular blocking properties of arbekacin, astromicin, isepamicin and netilmicin in the rabbit]. Jpn J Antibiot. 1999 Aug;52(8):554-61. Japanese. PubMed PMID: 10587880. 14: Sato K, Yamashita K, Okachi R. [In vivo combination effects of astromicin and beta-lactam antibiotics against Pseudomonas aeruginosa]. Jpn J Antibiot. 1986 Jun;39(6):1487-93. Japanese. PubMed PMID: 3093728. 15: Kawamura N, Okada K, Tanaka N, Kumamoto Y, Kishi H, Niijima T, Goto H, Machida T, Suzuki K, Naide Y, et al. [Clinical evaluation of astromicin administered by intravenous drip infusion. Report III. Bacterial infections in the field of urology]. Jpn J Antibiot. 1986 Nov;39(11):2945-58. Japanese. PubMed PMID: 3102807. 16: Kobayashi S, Inoue A, Deguchi T. [The pharmacokinetic studies on astromicin in dogs. Intramuscular, intravenous or drip intravenous administration]. Jpn J Antibiot. 1986 Jun;39(6):1443-52. Japanese. PubMed PMID: 3761558. 17: Iyama Y, Sato K, Okachi R. [In vitro combination effects of astromicin and beta-lactam antibiotics against Pseudomonas aeruginosa. In vitro synergistic activities]. Jpn J Antibiot. 1985 Apr;38(4):1022-8. Japanese. PubMed PMID: 3928940. 18: Hotta K, Ogata T, Ishikawa J, Okanishi M, Mizuno S, Morioka M, Naganawa H, Okami Y. Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273: involvement of two types of acetyltransferases in resistance to astromicin group antibiotics. J Antibiot (Tokyo). 1996 Jul;49(7):682-8. PubMed PMID: 8784431. 19: Kobayashi S, Takai K, Masuda S, Inoue A. [High performance liquid chromatographic determination of astromicin and piperacillin used in combination in blood samples]. Jpn J Antibiot. 1986 Dec;39(12):3156-63. Japanese. PubMed PMID: 3560434. 20: Yamasaku F, Kobayashi S, Inoue A. [Pharmacokinetic studies of astromicin using a constant-rate continuous intravenous infusion method]. Jpn J Antibiot. 1986 Jun;39(6):1473-9. Japanese. PubMed PMID: 3761560.

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