MedKoo Cat#: 130418 | Name: NRX-103094

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NRX-103094 increases the potency of the pSer33/Ser37 β-catenin peptide, increasing the binding affinity of S33E/S37A to β-TrCP.

Chemical Structure

NRX-103094
NRX-103094
CAS# 2763260-36-0

Theoretical Analysis

MedKoo Cat#: 130418

Name: NRX-103094

CAS#: 2763260-36-0

Chemical Formula: C20H11Cl2F3N2O4S

Exact Mass: 501.9769

Molecular Weight: 503.27

Elemental Analysis: C, 47.73; H, 2.20; Cl, 14.09; F, 11.32; N, 5.57; O, 12.72; S, 6.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NRX-103094; NRX 103094; NRX103094
IUPAC/Chemical Name
3-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamido)benzoic acid
InChi Key
HFBGFWJURBVNFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H11Cl2F3N2O4S/c21-11-5-2-6-12(22)16(11)32-13-8-14(20(23,24)25)27-18(29)15(13)17(28)26-10-4-1-3-9(7-10)19(30)31/h1-8H,(H,26,28)(H,27,29)(H,30,31)
SMILES Code
O=C(O)C1=CC=CC(NC(C2=C(SC3=C(Cl)C=CC=C3Cl)C=C(C(F)(F)F)NC2=O)=O)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 503.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Simonetta KR, Taygerly J, Boyle K, Basham SE, Padovani C, Lou Y, Cummins TJ, Yung SL, von Soly SK, Kayser F, Kuriyan J, Rape M, Cardozo M, Gallop MA, Bence NF, Barsanti PA, Saha A. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. doi: 10.1038/s41467-019-09358-9. PMID: 30926793; PMCID: PMC6441019.