MedKoo Cat#: 130410 | Name: (R)-SKBG-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-SKBG-1, a covalent NONO ligand, engages C145 of NONO, resulting in decreased proliferation of cancerous cells.

Chemical Structure

(R)-SKBG-1
(R)-SKBG-1
CAS#2955634-67-8 (R-isomer)

Theoretical Analysis

MedKoo Cat#: 130410

Name: (R)-SKBG-1

CAS#: 2955634-67-8 (R-isomer)

Chemical Formula: C22H26ClN3O6S

Exact Mass: 495.1231

Molecular Weight: 495.98

Elemental Analysis: C, 53.28; H, 5.28; Cl, 7.15; N, 8.47; O, 19.35; S, 6.46

Price and Availability

Size Price Availability Quantity
10mg USD 750.00 2 Weeks
25mg USD 1,250.00 2 Weeks
50mg USD 1,650.00 2 Weeks
100mg USD 2,950.00 2 Weeks
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Synonym
(R)-SKBG-1; (R)-SKBG 1; (R)-SKBG1
IUPAC/Chemical Name
(R)-4-(2-chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide
InChi Key
SXQZEMXQTRNLRZ-HXUWFJFHSA-N
InChi Code
InChI=1S/C22H26ClN3O6S/c1-31-17-5-3-16(4-6-17)14-24-22(28)20-15-25(21(27)13-23)11-12-26(20)33(29,30)19-9-7-18(32-2)8-10-19/h3-10,20H,11-15H2,1-2H3,(H,24,28)/t20-/m1/s1
SMILES Code
O=C([C@@H]1N(S(=O)(C2=CC=C(OC)C=C2)=O)CCN(C(CCl)=O)C1)NCC3=CC=C(OC)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kathman SG, Koo SJ, Lindsey GL, Her HL, Blue SM, Li H, Jaensch S, Remsberg JR, Ahn K, Yeo GW, Ghosh B, Cravatt BF. Remodeling oncogenic transcriptomes by small molecules targeting NONO. Nat Chem Biol. 2023 Mar 2. doi: 10.1038/s41589-023-01270-0. Epub ahead of print. PMID: 36864190.