MedKoo Cat#: 130399 | Name: A1V1PF2-OEt-C10-NH2 hydrochloride
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A1V1PF2-OEt-C10-NH2 hydrochloride is a vital component in the synthesis of targeted protein degraders and specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). The conjugate is comprised of an IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine, with the pendant amine reacting with an acid on a target warhead.

Chemical Structure

A1V1PF2-OEt-C10-NH2 hydrochloride
A1V1PF2-OEt-C10-NH2 hydrochloride
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130399

Name: A1V1PF2-OEt-C10-NH2 hydrochloride

CAS#: N/A

Chemical Formula: C35H59ClFN5O5

Exact Mass: 0.0000

Molecular Weight: 684.34

Elemental Analysis: C, 61.43; H, 8.69; Cl, 5.18; F, 2.78; N, 10.23; O, 11.69

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
A1V1PF2-OEt-C10-NH2 hydrochloride;A1V1PF2-OEt-C10-NH2 HCl
IUPAC/Chemical Name
ethyl (S)-2-((S)-1-((S)-2-((S)-2-((10-aminodecyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate hydrochloride
InChi Key
QUKDWZWTEXJGJX-LODWOWGDSA-N
InChi Code
InChI=1S/C35H58FN5O5.ClH/c1-6-46-34(45)28(24-26-17-19-27(36)20-18-26)39-32(43)29-16-15-23-41(29)33(44)30(35(3,4)5)40-31(42)25(2)38-22-14-12-10-8-7-9-11-13-21-37;/h17-20,25,28-30,38H,6-16,21-24,37H2,1-5H3,(H,39,43)(H,40,42);1H/t25-,28-,29-,30+;/m0./s1
SMILES Code
O=C(OCC)[C@@H](NC([C@H]1N(C([C@@H](NC([C@@H](NCCCCCCCCCCN)C)=O)C(C)(C)C)=O)CCC1)=O)CC2=CC=C(F)C=C2.Cl
Appearance
To be determined
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 684.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Naito M, Ohoka N, Shibata N. SNIPERs-Hijacking IAP activity to induce protein degradation. Drug Discov Today Technol. 2019 Apr;31:35-42. doi: 10.1016/j.ddtec.2018.12.002. Epub 2019 Jan 14. PMID: 31200857.