Pomalidomide-PEG5-Alkyne is a building block in the synthesis of targeted protein degraders and PROTACs. The conjugate contains a (CRBN)-recruiting ligand and a PEGylated crosslinker with a pendant alkyne. The alkyne is used in click chemistry with an azide on the target ligand.
MedKoo Cat#: 130395
Name: Pomalidomide-PEG5-Alkyne
CAS#: N/A
Chemical Formula: C27H33N3O10
Exact Mass: 559.2166
Molecular Weight: 559.57
Elemental Analysis: C, 57.95; H, 5.94; N, 7.51; O, 28.59
The following data is based on the product molecular weight 559.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
