MedKoo Cat#: 532787 | Name: SR142948A HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR 142948A is a non-peptide neurotensin receptor antagonist. It affects the expression of c-Fos and has properties of antipsychotic agent. SR142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concentration of Ca+2 induced by the activation of phospholipase C in CHO cell model.

Chemical Structure

SR142948A HCl
CAS#184162-21-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 532787

Name: SR142948A HCl

CAS#: 184162-21-8 (HCl)

Chemical Formula: C39H52ClN5O6

Exact Mass: 685.3839

Molecular Weight: 722.32

Elemental Analysis: C, 64.85; H, 7.26; Cl, 4.91; N, 9.70; O, 13.29

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Related CAS #
184162-64-9 (free base) 184162-21-8 (HCl) 184162-65-0 (sulfate) 184162-66-1 (besylate)
Synonym
SR142948A; SR 142948A; SR-142948A; SR142948A HCl; SR142948A hydrochloride
IUPAC/Chemical Name
2-[[5-(2,6-dimethoxyphenyl)-1-[4-(3-dimethylaminopropyl-methylcarbamoyl)-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid hydrochloride
InChi Key
CUYNEHGBVHUQQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C39H51N5O6.ClH/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24;/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48);1H
SMILES Code
O=C(C1(NC(C2=NN(C3=CC=C(C(N(CCCN(C)C)C)=O)C=C3C(C)C)C(C4=C(OC)C=CC=C4OC)=C2)=O)C5CC6CC(C5)CC1C6)O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 722.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Azmi N, Norman C, Spicer CH, Bennett GW. Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behav Pharmacol. 2006 Jun;17(4):357-62. PubMed PMID: 16914954. 2: Kreitel KD, Swisher CB, Behbehani MM. The effects of diphenhydramine and SR142948A on periaqueductal gray neurons and on the interactions between the medial preoptic nucleus and the periaqueductal gray. Neuroscience. 2002;114(4):935-43. PubMed PMID: 12379249. 3: Schaeffer P, Laplace MC, Bernat A, Prabonnaud V, Gully D, Lespy L, Herbert JM. SR142948A is a potent antagonist of the cardiovascular effects of neurotensin. J Cardiovasc Pharmacol. 1998 Apr;31(4):545-50. PubMed PMID: 9554803.