Validamycin A | CAS#37248-47-8

MedKoo Cat#: 333098 | Name: Validamycin A

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Validamycin A, also known as Validacin, is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9 nM; IC50 = 0.7 μM). Validamycin A Induces Broad-Spectrum Resistance Involving Salicylic Acid and Jasmonic Acid/Ethylene Signaling Pathways.

Chemical Structure

Validamycin A

CAS#37248-47-8

Theoretical Analysis

MedKoo Cat#: 333098

Name: Validamycin A

CAS#: 37248-47-8

Chemical Formula: C20H35NO13

Exact Mass: 497.2108

Molecular Weight: 497.49

Elemental Analysis: C, 48.29; H, 7.09; N, 2.82; O, 41.81

Price and Availability

Size	Price	Availability
100mg	USD 350.00	2 Weeks
200mg	USD 550.00	2 Weeks
500mg	USD 1,250.00	2 Weeks
1g	USD 2,250.00	2 Weeks

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Synonym

Validamycin A,

IUPAC/Chemical Name

(2R,3R,4S,5S,6R)-2-(((1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-(((1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl)amino)cyclohexyl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

InChi Key

JARYYMUOCXVXNK-CSLFJTBJSA-N

InChi Code

InChI=1S/C20H35NO13/c22-3-6-1-8(12(26)15(29)11(6)25)21-9-2-7(4-23)19(17(31)13(9)27)34-20-18(32)16(30)14(28)10(5-24)33-20/h1,7-32H,2-5H2/t7-,8+,9+,10-,11-,12+,13+,14-,15+,16+,17-,18-,19-,20+/m1/s1

SMILES Code

O[C@H]([C@H]1O)[C@H](O)[C@@H](CO)O[C@@]1([H])O[C@H]2[C@H](O)[C@@H](O)[C@@H](N[C@@]3([H])C=C(CO)[C@@H](O)[C@H](O)[C@H]3O)C[C@@H]2CO

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 497.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu Y, Yang F, Wan S, Wang X, Guan L, Li Y, Xu C, Xie B, Wang S, Tan XL, Tang B. Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition. BMC Genomics. 2025 Feb 1;26(1):98. doi: 10.1186/s12864-025-11268-8. PMID: 39893429; PMCID: PMC11787742. 2: Zhang H, Li H, Fang S, Guan D, Wei J, Wang Z, Luo Z, Qian K, Wang J. Co- application of Validamycin A and dsRNAs targeting trehalase genes conferred enhanced insecticidal activity against Laodelphax striatellus. Pestic Biochem Physiol. 2024 Nov;205:106160. doi: 10.1016/j.pestbp.2024.106160. Epub 2024 Oct 3. PMID: 39477613. 3: Tian Z, Qiao Y, Xie D, Puqian A, Zhang L, Cheng Y, Jiang X, Michaud JP. Trehalose metabolism mediates trade-offs between reproduction and survival in beet webworm, Loxostege sticticalis, under heat stress. Pest Manag Sci. 2025 Feb;81(2):903-911. doi: 10.1002/ps.8492. Epub 2024 Oct 22. PMID: 39435696. 4: Chen Z, Cao H, Jin J, Li Z, Zhang S, Chen J. Enhanced Antifungal Efficacy of Validamycin A Co-Administered with Bacillus velezensis TCS001 against Camellia anthracnose. Plants (Basel). 2024 Sep 30;13(19):2743. doi: 10.3390/plants13192743. PMID: 39409613; PMCID: PMC11479143. 5: Ogunnupebi TA, Oduselu GO, Elebiju OF, Ajani OO, Adebiyi E. In silico studies of benzothiazole derivatives as potential inhibitors of Anopheles funestus and Anopheles gambiae trehalase. Front Bioinform. 2024 Aug 9;4:1428539. doi: 10.3389/fbinf.2024.1428539. PMID: 39184337; PMCID: PMC11341456. 6: Majid S, Ahmad KS, Yusuf K, Ashraf GA. Exploring the sorption and degradation dynamics of validamycin-A in agricultural soils for environmental management. Environ Geochem Health. 2024 Jul 29;46(9):340. doi: 10.1007/s10653-024-02124-x. PMID: 39073647. 7: Wu L, Shi L, Fan L, Pan Z, Zhao Z, Su H, Wang C, Yang N, Xu C, Yang G. Synthesis and Antifungal Activities of Glucosamine Aromatic Derivatives Against Four Phytopathogenic Fungi of Crops. Chem Biodivers. 2024 Nov;21(11):e202401052. doi: 10.1002/cbdv.202401052. Epub 2024 Sep 26. PMID: 39058413. 8: Tellis M, Mohite S, Joshi R. Trehalase inhibition in Helicoverpa armigera activates machinery for alternate energy acquisition. J Biosci. 2024;49:74. PMID: 39046035. 9: Gu SH, Lin PL, Chang CH. Expressions of sugar transporters/trehalases in relation to PTTH-stimulated ecdysteroidogenesis in the silkworm, Bombyx mori. J Insect Physiol. 2024 Sep;157:104672. doi: 10.1016/j.jinsphys.2024.104672. Epub 2024 Jul 7. PMID: 38981575. 10: Zhao B, Li J, Zhou L, Liu W, Geng S, Zhao Y, Hou Z, Zhao R, Liu Y, Dong J. Validamycin A Inhibited FB1 Biosynthesis by the Target FvNth in Fusarium verticillioides. J Agric Food Chem. 2024 Jul 17;72(28):15487-15497. doi: 10.1021/acs.jafc.4c02641. Epub 2024 Jun 25. PMID: 38917402. 11: Lee E, Banik A, Lee KB, Sim SM, Kil AH, Hwang BJ, Kee Y. Assessment of the Novel Anti-Seizure Potential of Validamycin A Using Zebrafish Epilepsy Model. Molecules. 2024 May 30;29(11):2572. doi: 10.3390/molecules29112572. PMID: 38893448; PMCID: PMC11173475. 12: Xia T, Zhu X, Zhan Y, Liu B, Zhou X, Zhang Q, Xu W. The white lupin trehalase gene LaTRE1 regulates cluster root formation and function under phosphorus deficiency. Plant Physiol. 2024 Dec 2;196(4):2184-2198. doi: 10.1093/plphys/kiae290. PMID: 38805210; PMCID: PMC11637477. 13: Neyman V, Quicray M, Francis F, Michaux C. Toxicological, biochemical, and in silico investigations of three trehalase inhibitors for new ways to control aphids. Arch Insect Biochem Physiol. 2024 Apr;115(4):e22112. doi: 10.1002/arch.22112. PMID: 38605672. 14: Mohanan A, Kodigudla A, Raman DR, Bakka K, Challabathula D. Trehalose accumulation enhances drought tolerance by modulating photosynthesis and ROS- antioxidant balance in drought sensitive and tolerant rice cultivars. Physiol Mol Biol Plants. 2023 Dec;29(12):2035-2049. doi: 10.1007/s12298-023-01404-7. Epub 2023 Dec 28. PMID: 38222274; PMCID: PMC10784439. 15: Feng R, Sun B, Zhang S, Su E, Kovalevsky A, Zhang F, Bennett BC, Shen Q, Wan Q. Discovery of Novel Rhizoctonia solani DHFR Inhibitors as Fungicides Using Virtual Screening. J Agric Food Chem. 2023 Dec 13;71(49):19385-19395. doi: 10.1021/acs.jafc.3c05216. Epub 2023 Dec 1. PMID: 38038282. 16: Zhu H, Ahmad S, Duan Z, Shi J, Tang X, Dong Q, Xi C, Ge L, Wu T, Tan Y. The Jinggangmycin-induced Mthl2 gene regulates the development and stress resistance in Nilaparvata lugens Stål (Hemiptera: Delphacidae). Pestic Biochem Physiol. 2023 Nov;196:105630. doi: 10.1016/j.pestbp.2023.105630. Epub 2023 Sep 29. PMID: 37945234. 17: Li T, Wang Q, Yang Y, Song D. The mechanism of polysaccharide synthesis of Sanghuangporus sanghuang based on multi-omic analyses and feedback inhibition. Carbohydr Polym. 2023 Dec 1;321:121288. doi: 10.1016/j.carbpol.2023.121288. Epub 2023 Aug 11. PMID: 37739500. 18: Turna Demir F, Demir E. In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain. J Appl Toxicol. 2024 Mar;44(3):355-370. doi: 10.1002/jat.4547. Epub 2023 Sep 21. PMID: 37735745. 19: Song Y, Gu F, Li Y, Zhou W, Wu FA, Wang J, Sheng S. Host trehalose metabolism disruption by validamycin A results in reduced fitness of parasitoid offspring. Pestic Biochem Physiol. 2023 Sep;195:105570. doi: 10.1016/j.pestbp.2023.105570. Epub 2023 Aug 7. PMID: 37666623. 20: Dong W, Wu WJ, Song CY, Li T, Zhang JZ. Jinggangmycin stimulates reproduction and increases CHCs-dependent desiccation tolerance in Drosophila melanogaster. Pestic Biochem Physiol. 2023 Aug;194:105484. doi: 10.1016/j.pestbp.2023.105484. Epub 2023 May 30. PMID: 37532348.