SLB1122168 is a potent inhibitor (IC50 = 94 ± 6 nM) of Spns2-mediated S1P release. Administration of SLB1122168 to mice and rats resulted in a dose dependent decrease in circulating lymphocytes, a pharmacodynamic indication of Spns2 inhibition. SLB1122168 provides a valuable tool compound to explore both the therapeutic potential of targeting Spns2 and the physiologic consequences of selective S1P export inhibition.
MedKoo Cat#: 123111
Name: SLB1122168 HCl
CAS#: 2999629-17-1 (HCl)
Chemical Formula: C22H36ClN3O
Exact Mass: 393.2500
Molecular Weight: 394.00
Elemental Analysis: C, 67.07; H, 9.21; Cl, 9.00; N, 10.67; O, 4.06
The following data is based on the product molecular weight 394.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
