Synonym
BCH-24426; BCH24426; BCH 24426; 3-Hydroxy Anagrelide
IUPAC/Chemical Name
6,7-dichloro-3-hydroxy-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
InChi Key
KAXTUTDKZVOONF-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H7Cl2N3O2/c11-5-1-2-6-4(7(5)12)3-15-9(17)8(16)14-10(15)13-6/h1-2,9,17H,3H2,(H,13,14,16)
SMILES Code
O=C1C(O)N2CC3=C(Cl)C(Cl)=CC=C3N=C2N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
272.09
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S,
Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M,
Komatsu N. Skewed megakaryopoiesis in human induced pluripotent stem cell-
derived haematopoietic progenitor cells harbouring calreticulin mutations. Br J
Haematol. 2018 Jun;181(6):791-802. doi: 10.1111/bjh.15266. Epub 2018 May 9.
PMID: 29741776.
2.Wang G, Franklin R, Hong Y, Erusalimsky JD. Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. doi: 10.1038/sj.bjp.0706341. PMID: 16041400; PMCID: PMC1576287.
