MedKoo Cat#: 123054 | Name: CDK-IN-2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDK-IN-2 is a potent and specific CDK9 inhibitor.

Chemical Structure

CDK-IN-2
CAS#1269815-17-9

Theoretical Analysis

MedKoo Cat#: 123054

Name: CDK-IN-2

CAS#: 1269815-17-9

Chemical Formula: C18H19ClFN3O2

Exact Mass: 363.1100

Molecular Weight: 363.82

Elemental Analysis: C, 59.42; H, 5.26; Cl, 9.74; F, 5.22; N, 11.55; O, 8.80

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
10mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
CDK-IN-2; CDK inhibitor II;
IUPAC/Chemical Name
(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide
InChi Key
AHMKHNVZGOQLRQ-LLVKDONJSA-N
InChi Code
InChI=1S/C18H19ClFN3O2/c1-25-16-5-4-12(20)7-14(16)13-8-17(22-10-15(13)19)23-18(24)11-3-2-6-21-9-11/h4-5,7-8,10-11,21H,2-3,6,9H2,1H3,(H,22,23,24)/t11-/m1/s1
SMILES Code
COC1=C(C=C(C=C1)F)C2=CC(=NC=C2Cl)NC(=O)[C@@H]3CCCNC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Krulikas LJ, McDonald IM, Lee B, Okumu DO, East MP, Gilbert TSK, Herring LE, Golitz BT, Wells CI, Axtman AD, Zuercher WJ, Willson TM, Kireev D, Yeh JJ, Johnson GL, Baines AT, Graves LM. Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth. SLAS Discov. 2018 Sep;23(8):850-861. doi: 10.1177/2472555218773045. Epub 2018 May 9. PMID: 29742358; PMCID: PMC6102050.