ZZ151 is a Potent, Cooperative, and Selective SOS1 PROTAC with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers. ZZ151 quickly, specifically, and effectively induced SOS1 degradation; displayed potent antiproliferation activities against a broad panel of KRAS mutant-driven cancer cells; and showed superior anticancer activities in the KRASG12D- and G12V-mutant xenografts in mice. ZZ151 is a promising lead for developing new chemotherapies targeting KRAS mutants.
MedKoo Cat#: 123021
Name: ZZ151
CAS#: N/A
Chemical Formula: C54H68F3N9O6S
Exact Mass: 1027.5000
Molecular Weight: 1028.25
Elemental Analysis: C, 63.08; H, 6.67; F, 5.54; N, 12.26; O, 9.34; S, 3.12
The following data is based on the product molecular weight 1,028.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
