Factor 390 A | CAS#95617-07-5 | phosphodiester

MedKoo Cat#: 597252 | Name: Factor 390 A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Factor 390 A is the phosphodiester between AMP & methanogen factor 420.

Chemical Structure

Factor 390 A

CAS#95617-07-5

Theoretical Analysis

MedKoo Cat#: 597252

Name: Factor 390 A

CAS#: 95617-07-5

Chemical Formula: C39H48N10O24P2

Exact Mass: 1102.2318

Molecular Weight: 1102.80

Elemental Analysis: C, 42.48; H, 4.39; N, 12.70; O, 34.82; P, 5.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Factor 390 A; F390-A; F390 A; F390A; coenzyme F390-A

IUPAC/Chemical Name

((4S)-4-((2S)-2-(((((2R,3S,4S)-5-(8-(((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-2,3,4-trihydroxypentyl)oxy)(hydroxy)phosphoryl)oxy)propanamido)-4-carboxybutanoyl)-L-glutamic acid

InChi Key

WYXLWMBDMKFRML-CSDPJWOXSA-N

InChi Code

InChI=1S/C39H48N10O24P2/c1-15(34(58)45-20(38(62)63)4-6-25(52)44-19(37(60)61)5-7-26(53)54)72-74(65,66)69-11-23(51)28(55)22(50)10-48-21-9-17(3-2-16(21)8-18-32(48)46-39(64)47-35(18)59)73-75(67,68)70-12-24-29(56)30(57)36(71-24)49-14-43-27-31(40)41-13-42-33(27)49/h2-3,8-9,13-15,19-20,22-24,28-30,36,50-51,55-57H,4-7,10-12H2,1H3,(H,44,52)(H,45,58)(H,53,54)(H,60,61)(H,62,63)(H,65,66)(H,67,68)(H2,40,41,42)(H,47,59,64)/t15-,19-,20-,22-,23+,24+,28-,29+,30+,36+/m0/s1

SMILES Code

C[C@H](OP(O)(OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=C(C=C3C1=NC(NC3=O)=O)C=CC(OP(O)(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C=NC6=C(N)N=CN=C65)O4)=O)=C2)=O)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,102.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pennings JL, Keltjens JT, Vogels GD. Isolation and characterization of Methanobacterium thermoautotrophicum DeltaH mutants unable to grow under hydrogen-deprived conditions. J Bacteriol. 1998 May;180(10):2676-81. PubMed PMID: 9573152; PubMed Central PMCID: PMC107219. 2: Vermeij P, Pennings JL, Maassen SM, Keltjens JT, Vogels GD. Cellular levels of factor 390 and methanogenic enzymes during growth of Methanobacterium thermoautotrophicum deltaH. J Bacteriol. 1997 Nov;179(21):6640-8. PubMed PMID: 9352911; PubMed Central PMCID: PMC179590. 3: van de Wijngaard WM, vermey P, van der Drift C. Formation of factor 390 by cell extracts of Methanosarcina barkeri. J Bacteriol. 1991 Apr;173(8):2710-1. PubMed PMID: 2013583; PubMed Central PMCID: PMC207842. 4: Kengen SW, von den Hoff HW, Keltjens JT, van der Drift C, Vogels GD. Hydrolysis and reduction of factor 390 by cell extracts of Methanobacterium thermoautotrophicum (strain delta H). J Bacteriol. 1991 Apr;173(7):2283-8. PubMed PMID: 2007552; PubMed Central PMCID: PMC207780. 5: Gloss LM, Hausinger RP. Methanogen factor 390 formation: species distribution, reversibility and effects of non-oxidative cellular stresses. Biofactors. 1988 Oct;1(3):237-40. PubMed PMID: 2855706. 6: Hausinger RP, Orme-Johnson WH, Walsh C. Factor 390 chromophores: phosphodiester between AMP or GMP and methanogen factor 420. Biochemistry. 1985 Mar 26;24(7):1629-33. PubMed PMID: 2988607.