Synonym
KVN93; KVN 93; KVN-93
IUPAC/Chemical Name
(4-((4-(ethylamino)-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)-3-methoxyphenyl)(4-morpholinopiperidin-1-yl)methanone
InChi Key
FKRHOHUJMCOWDZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H33F3N6O3/c1-3-31-21-15-23(34-25-24(21)19(16-32-25)27(28,29)30)33-20-5-4-17(14-22(20)38-2)26(37)36-8-6-18(7-9-36)35-10-12-39-13-11-35/h4-5,14-16,18H,3,6-13H2,1-2H3,(H3,31,32,33,34)
SMILES Code
O=C(C1=CC=C(NC2=CC(NCC)=C3C(NC=C3C(F)(F)F)=N2)C(OC)=C1)N4CCC(N5CCOCC5)CC4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
546.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Lee HJ, Woo H, Lee HE, Jeon H, Ryu KY, Nam JH, Jeon SG, Park H, Lee JS, Han KM, Lee SM, Kim J, Kang RJ, Lee YH, Kim JI, Hoe HS. The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation. Free Radic Biol Med. 2020 Nov 20;160:575-595. doi: 10.1016/j.freeradbiomed.2020.08.030. Epub 2020 Sep 5. PMID: 32896600.
2. Pucelik B, Barzowska A, Dąbrowski JM, Czarna A. Diabetic Kinome Inhibitors-A New Opportunity for β-Cells Restoration. Int J Mol Sci. 2021 Aug 23;22(16):9083. doi: 10.3390/ijms22169083. PMID: 34445786; PMCID: PMC8396662.
