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MedKoo Cat#: 122960 | Name: PPZ-A10
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPZ-A10 is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo. LNPs formulated with PPZ-A10 preferentially delivered mRNA to the liver and spleen immune cells.

Chemical Structure

PPZ-A10
PPZ-A10
CAS#2941268-67-1

Theoretical Analysis

MedKoo Cat#: 122960

Name: PPZ-A10

CAS#: 2941268-67-1

Chemical Formula: C56H114N6O2

Exact Mass: 902.9000

Molecular Weight: 903.57

Elemental Analysis: C, 74.44; H, 12.72; N, 9.30; O, 3.54

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
PPZ-A10; PPZA10; PPZ A10
IUPAC/Chemical Name
N,N'-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(3-(didecylamino)propanamide)
InChi Key
PXNLDSAGMDIEAT-UHFFFAOYSA-N
InChi Code
InChI=1S/C56H114N6O2/c1-5-9-13-17-21-25-29-33-43-59(44-34-30-26-22-18-14-10-6-2)49-39-55(63)57-41-37-47-61-51-53-62(54-52-61)48-38-42-58-56(64)40-50-60(45-35-31-27-23-19-15-11-7-3)46-36-32-28-24-20-16-12-8-4/h5-54H2,1-4H3,(H,57,63)(H,58,64)
SMILES Code
CCCCCCCCCCN(CCC(NCCCN1CCN(CCCNC(CCN(CCCCCCCCCC)CCCCCCCCCC)=O)CC1)=O)CCCCCCCCCC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 903.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ni, H., Hatit, M. Z., Zhao, K., Loughrey, D., Lokugamage, M. P., Peck, H. E., ... & Dahlman, J. E. (2022). Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nature Communications, 13(1), 4766. Yang, Z., Liu, Y., Zhao, K., Jing, W., Gao, L., Dong, X., ... & Jiang, X. (2023). Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy. Journal of Ophthalmology Clinics and Research, 360, 718-733. Wu, S., Lin, L., Shi, L., & Liu, S. (2024). An overview of lipid constituents in lipid nanoparticle mRNA delivery systems. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 16(4), e1978. Qu, Y., Xu, J., Zhang, T., Chen, Q., Sun, T., & Jiang, C. (2024). Advanced nano-based strategies for mRNA tumor vaccine. Acta Pharmaceutica Sinica B, 14(1), 170-189. Subhan, M. A., & Torchilin, V. P. (2023). Biopolymer-based nanosystems for siRNA drug delivery to solid tumors including breast cancer. Pharmaceutics, 15(1), 153.