Osunprotafib, also known as ABBV-CLS-484 and AC-484, an inhibitor of PTPN2/N1, has shown promise as an anti-tumor agent. ABBV-CLS-484 increases cytotoxic T-cell activity and the susceptibility of tumor cells to the immune system. Phase 1 clinical trials are currently being undergone for ABBV-CLS-484, both as a monotherapy, and in combination with a PD-1 targeting agent for the treatment of relapsed or advanced HNSCC.
MedKoo Cat#: 130251
Name: Osunprotafib
CAS#: 2489404-97-7
Chemical Formula: C17H24FN3O4S
Exact Mass: 385.1472
Molecular Weight: 385.45
Elemental Analysis: C, 52.97; H, 6.28; F, 4.93; N, 10.90; O, 16.60; S, 8.32
The following data is based on the product molecular weight 385.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
