CB-5339 is a VCP/p97 inhibitor with the potential for use in anti-cancer therapy. By binding to p97, CB-5339 suppresses ubiquitin-dependent protein degradation, leading to the accumulation of poly-ubiquitinated proteins in cells, which activates the ER-dependent stress response pathway, causing apoptosis in tumor cells overexpressing p97. As of 2022, CB-5339 has been undergoing Phase 1 clinical trials for use in treating R/R AML (acute myeloid leukemia) and MDS.
MedKoo Cat#: 130250
Name: CB-5339
CAS#: 1863952-15-1
Chemical Formula: C24H24N6O
Exact Mass: 412.2012
Molecular Weight: 412.50
Elemental Analysis: C, 69.88; H, 5.86; N, 20.37; O, 3.88
The following data is based on the product molecular weight 412.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
