Synonym
TP-6076; TP6076; TP 6076;
IUPAC/Chemical Name
(4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-((S)-pyrrolidin-2-yl)-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
InChi Key
IDWTZCZXXFOLNV-DOYYSQEVSA-N
InChi Code
InChI=1S/C28H32F3N3O7/c1-3-34(4-2)21-14-9-11-8-13-18(16(35)10-12(15-6-5-7-33-15)20(13)28(29,30)31)22(36)17(11)24(38)27(14,41)25(39)19(23(21)37)26(32)40/h10-11,14-15,21,33,35,37-38,41H,3-9H2,1-2H3,(H2,32,40)/t11-,14-,15-,21-,27-/m0/s1
SMILES Code
O=C(C1=C(O)[C@@H](N(CC)CC)[C@@](C[C@@]2([H])C(C(C3=C(O)C=C([C@H]4NCCC4)C(C(F)(F)F)=C3C2)=O)=C5O)([H])[C@@]5(O)C1=O)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
579.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Morgan CE, Zhang Z, Bonomo RA, Yu EW. An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. mBio. 2022 Feb 1;13(1):e0373221. doi: 10.1128/mbio.03732-21. Epub ahead of print. PMID: 35100868; PMCID: PMC8805024.
2: Seifert H, Stefanik D, Olesky M, Higgins PG. In vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii. Int J Antimicrob Agents. 2020 Jan;55(1):105829. doi: 10.1016/j.ijantimicag.2019.10.010. Epub 2019 Dec 16. PMID: 31669740.
3: Falagas ME, Skalidis T, Vardakas KZ, Voulgaris GL, Papanikolaou G, Legakis N; Hellenic TP-6076 Study Group. Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. Int J Antimicrob Agents. 2018 Aug;52(2):269-271. doi: 10.1016/j.ijantimicag.2018.03.009. Epub 2018 Mar 17. PMID: 29559273.
4: Chahrour O, Malone J, Collins M, Salmon V, Greenan C, Bombardier A, Ma Z, Dunwoody N. Development and validation of an ICP-MS method for the determination of elemental impurities in TP-6076 active pharmaceutical ingredient (API) according to USP 〈232〉/〈233〉. J Pharm Biomed Anal. 2017 Oct 25;145:84-90. doi: 10.1016/j.jpba.2017.06.045. Epub 2017 Jun 20. PMID: 28654780.
