Synonym
Moracin C; Moracin-C; MoracinC
IUPAC/Chemical Name
1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)-
InChi Key
ZTGHWUWBQNCCOH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18O4/c1-11(2)3-6-15-16(21)7-13(8-17(15)22)18-9-12-4-5-14(20)10-19(12)23-18/h3-5,7-10,20-22H,6H2,1-2H3
SMILES Code
OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1C/C=C(C)\C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
310.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Parise A, De Simone BC, Marino T, Toscano M, Russo N. Quantum Mechanical Predictions of the Antioxidant Capability of Moracin C Isomers. Front Chem. 2021 Apr 21;9:666647. doi: 10.3389/fchem.2021.666647. PMID: 33968905; PMCID: PMC8097241.
2: Masagalli JN, BasavanaGowda MK, Chae HS, Choi WJ. Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells. Molecules. 2021 Mar 2;26(5):1327. doi: 10.3390/molecules26051327. PMID: 33801308; PMCID: PMC7958322.
3: You BH, BasavanaGowda MK, Lee JU, Chin YW, Choi WJ, Choi YH. Correction: Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Feb 5. doi: 10.1055/a-1384-8484. Epub ahead of print. Erratum for: Planta Med. 2021 Jan 26;: PMID: 33545721.
4: You BH, BasavanaGowda MK, Lee JU, Chin YW, Choi WJ, Choi YH. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651. doi: 10.1055/a-1321-1519. Epub 2021 Jan 26. Erratum in: Planta Med. 2021 Feb 05;: PMID: 33498088.
5: Li X, Xie H, Zhan R, Chen D. Effect of Double Bond Position on 2-Phenyl- benzofuran Antioxidants: A Comparative Study of Moracin C and Iso-Moracin C. Molecules. 2018 Mar 24;23(4):754. doi: 10.3390/molecules23040754. PMID: 29587376; PMCID: PMC6017532.
6: Yao X, Wu D, Dong N, Ouyang P, Pu J, Hu Q, Wang J, Lu W, Huang J. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25;17(8):1199. doi: 10.3390/ijms17081199. PMID: 27463712; PMCID: PMC5000597.
7: Kim YJ, Sohn MJ, Kim WG. Chalcomoracin and moracin C, new inhibitors of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba. Biol Pharm Bull. 2012;35(5):791-5. doi: 10.1248/bpb.35.791. PMID: 22687419.
