AM11095 is an inhibitor of NAAA with demonstrated potential as a cancer therapeutic agent with an IC₅₀ of 20 nM. NAAA is an enzyme responsible for degrading palmitoylethanolamide (PEA), an endogenous lipid mediator with anti-inflammatory and neuroprotective properties. By inhibiting NAAA, AM11095 elevates PEA levels, leading to anti-inflammatory effects. Studies have demonstrated that AM11095 reduces the secretion of pro-inflammatory cytokines such as IL-6 and IL-8, decreases activation of the NF-κB pathway, and inhibits tumor cell migration in triple-negative breast cancer models.
MedKoo Cat#: 130224
Name: AM11095
CAS#: 1831115-37-7 (free base)
Chemical Formula: C18H17FN2O2S
Exact Mass: 344.0995
Molecular Weight: 344.40
Elemental Analysis: C, 62.77; H, 4.98; F, 5.52; N, 8.13; O, 9.29; S, 9.31
The following data is based on the product molecular weight 344.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
